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Showing 1–2 of 2 results
Advanced filters: Author: Hanah Goetz Clear advanced filters

  • Synthetic gene circuits may not function as expected due to the resource competition between modules. Here the authors build cascading bistable switches to achieve two successive cell fate transitions but found a ‘winner-takes-all’ behaviour, which is overcome by a division of labour strategy.

    • Rong Zhang
    • Hanah Goetz
    • Xiao-Jun Tian
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-9

  • Synthetic circuit-host interactions affect the performance synthetic biology systems. Analysis of two bi-stable switch circuits reveals differential effects of host growth on circuit memory, which is dependent on the network topology of the circuit.

    • Rong Zhang
    • Jiao Li
    • Xiao-Jun Tian
    Research
    Nature Chemical Biology
    Volume: 16, P: 695-701