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Showing 1–3 of 3 results
Advanced filters: Author: Hangxue Xu Clear advanced filters

  • Fibrocystin/Polyductin (FPC) is a large ciliary membrane protein encoded by PKHD1 which, when mutated, causes ARPKD. Here, the authors show that FPC suppresses cyst development in the kidney of mouse models through the release and mitochondrial translocation of its C terminal product.

    • Rebecca V Walker
    • Qin Yao
    • Feng Qian
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17

  • Polycystins (PC) 1 and 2 are large transmembrane proteins that play a vital role in the function of primary cilia. Here, Kim et al. identify the requirements for polycystin trafficking to the cilium, involving a PC1–PC2 interaction, PC1 proteolytic cleavage and a specific trafficking module at the trans-Golgi network.

    • Hyunho Kim
    • Hangxue Xu
    • Feng Qian
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-13

  • Polycystic kidney disease is marked by progressive growth of renal tubular epithelia and thus the formation of pathological cysts in the organ over time. Alessandra Boletta and her colleagues now show that this cystic growth has the hallmarks of the Warburg effect (that is, the primary reliance of cells on glycolysis for their energy demands) and that blocking this effect in vivo is sufficient to improve disease progression in two mouse models.

    • Isaline Rowe
    • Marco Chiaravalli
    • Alessandra Boletta
    Research
    Nature Medicine
    Volume: 19, P: 488-493