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Co-delivery of sorafenib and an FSP1 inhibitor triggers dual ferroptosis in tumor cells and immunosuppressive macrophages for enhanced immunotherapy in mouse models of hepatocellular carcinoma

The high abundance of immunosuppressive, tumor-associated macrophages limits the efficacy of treatments against hepatocellular carcinoma. Here, the authors develop a nanoplatform for the co-delivery of FSP1 inhibitor and sorafenib that simultaneously targets tumor cells and M2-like macrophages, inducing ferroptosis and boosting anti-tumor immune responses in preclinical mouse models.

Chuanyu Tang
Cheng He
Chihua Fang
ResearchOpen Access18 Nov 2025
Nature Communications

Volume: 16, P: 1-23
Design of a two-dimensional interplanar heterojunction for catalytic cancer therapy

Chemodynamic therapy relies on Fenton or Fenton-like reactions to produce hydroxyl radical in the tumor region. Here the authors design a two-dimensional interplanar heterojunction with in situ hydroxyl radical generation under ultrasound irradiation, showing anti-cancer activity in preclinical models.

Yong Kang
Zhuo Mao
Xiaoyuan Ji
ResearchOpen Access03 May 2022
Nature Communications

Volume: 13, P: 1-20
Uncoupling histone modification crosstalk by engineering lysine demethylase LSD1

Lee, Barone et al. engineered a mutant form of LSD1, Y391K, which renders the nucleosome demethylase activity of LSD1 insensitive to Lys14 acetylation of histone H3, providing a useful tool to illuminate the functional consequences of disconnecting histone modification crosstalk.

Kwangwoon Lee
Marco Barone
Philip A. Cole
Research04 Jul 2024
Nature Chemical Biology

Volume: 21, P: 227-237
Intelligent planetary gear fault diagnosis system based on MEMS acoustic emission sensor

Hanjie Dou
Tao Liu
Xiaojing Mu
ResearchOpen Access18 Jun 2025
Microsystems & Nanoengineering

Volume: 11, P: 1-10
Boosting effect of strong western pole of the Indian Ocean Dipole on the decay of El Niño events

Jia Wu
Hanjie Fan
Song Yang
ResearchOpen Access03 Jan 2024
npj Climate and Atmospheric Science

Volume: 7, P: 1-11
Knockout of OsNramp5 using the CRISPR/Cas9 system produces low Cd-accumulating indica rice without compromising yield

Li Tang
Bigang Mao
Bingran Zhao
ResearchOpen Access31 Oct 2017
Scientific Reports

Volume: 7, P: 1-12
Discovery of biclonal origin and a novel oncogene SLC12A5 in colon cancer by single-cell sequencing

Chang Yu
Jun Yu
Jun Wang
Research04 Apr 2014
Cell Research

Volume: 24, P: 701-712

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Co-delivery of sorafenib and an FSP1 inhibitor triggers dual ferroptosis in tumor cells and immunosuppressive macrophages for enhanced immunotherapy in mouse models of hepatocellular carcinoma

Design of a two-dimensional interplanar heterojunction for catalytic cancer therapy

Uncoupling histone modification crosstalk by engineering lysine demethylase LSD1

Intelligent planetary gear fault diagnosis system based on MEMS acoustic emission sensor

Boosting effect of strong western pole of the Indian Ocean Dipole on the decay of El Niño events

Knockout of OsNramp5 using the CRISPR/Cas9 system produces low Cd-accumulating indica rice without compromising yield

Discovery of biclonal origin and a novel oncogene SLC12A5 in colon cancer by single-cell sequencing

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Co-delivery of sorafenib and an FSP1 inhibitor triggers dual ferroptosis in tumor cells and immunosuppressive macrophages for enhanced immunotherapy in mouse models of hepatocellular carcinoma

Design of a two-dimensional interplanar heterojunction for catalytic cancer therapy

Uncoupling histone modification crosstalk by engineering lysine demethylase LSD1

Intelligent planetary gear fault diagnosis system based on MEMS acoustic emission sensor

Boosting effect of strong western pole of the Indian Ocean Dipole on the decay of El Niño events

Knockout of OsNramp5 using the CRISPR/Cas9 system produces low Cd-accumulating indica rice without compromising yield

Discovery of biclonal origin and a novel oncogene SLC12A5 in colon cancer by single-cell sequencing

Search

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