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Showing 1–3 of 3 results
Advanced filters: Author: Hannah L. Watry Clear advanced filters

  • Genome editing tools can precisely introduce a specified lesion into the DNA, but ultimately rely on the cell’s DNA repair machinery to determine the editing outcome. Here, authors demonstrate how neurons’ unique DNA repair pathways impact the safety, efficiency, and precision of CRISPR edits.

    • Gokul N. Ramadoss
    • Samali J. Namaganda
    • Bruce R. Conklin
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • Perez-Bermejo et al. performed an in-depth study on a variant in the BAG3 gene that has been previously associated with lowered incidence of heart failure and show that, in induced pluripotent stem cell-derived cardiomyocytes engineered to express such BAG3 variant, the interactome of the corresponding BAG3 protein has changed, rendering the engineered cardiomyocytes more resistant to a well-known cardiotoxic drug.

    • Juan A. Perez-Bermejo
    • Luke M. Judge
    • Bruce R. Conklin
    Research
    Nature Cardiovascular Research
    Volume: 2, P: 615-628