Nature Search

A synergistic mindsets intervention protects adolescents from stress

An online training module that synergistically targets two different mindsets can reduce stress levels in adolescents in the context of social-evaluative stressors—stressful experiences in which individuals fear that others are judging them negatively.

David S. Yeager
Christopher J. Bryan
Jeremy P. Jamieson
ResearchOpen Access06 Jul 2022
Nature

Volume: 607, P: 512-520
Silent synapses dictate cocaine memory destabilization and reconsolidation

Cocaine-generated silent synapses dictate the encoding, consolidation, retrieval-induced destabilization and reconsolidation of cocaine memories, and these syapses can be targeted to reduce drug seeking and relapse.

William J. Wright
Nicholas M. Graziane
Yan Dong
Research02 Dec 2019
Nature Neuroscience

Volume: 23, P: 32-46
Early life stress alters transcriptomic patterning across reward circuitry in male and female mice

Early life stress alters behavioural response to adult stress in female mice. Here authors transcriptionally profile three brain regions involved in reward (ventral tegmental area, nucleus accumbens, and prefrontal cortex) in both male and female adult mice after early life and/or adult stress

Catherine Jensen Peña
Milo Smith
Eric J. Nestler
ResearchOpen Access08 Nov 2019
Nature Communications

Volume: 10, P: 1-13
Adeno-associated virus type 2 in US children with acute severe hepatitis

A retrospective analysis using PCR testing, viral enrichment-based sequencing and agnostic metagenomic sequencing finds an association between adeno-associated virus type 2 and paediatric hepatitis of unknown cause.

Venice Servellita
Alicia Sotomayor Gonzalez
Charles Y. Chiu
Research30 Mar 2023
Nature

Volume: 617, P: 574-580
Locus-specific epigenetic remodeling controls addiction- and depression-related behaviors

The authors selectively modify chromatin in a specific gene in vivo to examine the link between chromatin dynamics and drug- and stress-evoked responses. They report that histone methylation or acetylation at the FosB locus in nucleus accumbens is sufficient to control drug- and stress-evoked transcriptional and behavioral responses.

Elizabeth A Heller
Hannah M Cates
Eric J Nestler
Research27 Oct 2014
Nature Neuroscience

Volume: 17, P: 1720-1727
MicroRNAs 146a/b-5 and 425-3p and 24-3p are markers of antidepressant response and regulate MAPK/Wnt-system genes

Antidepressant drugs are the most common treatment for depressive episodes but only a fraction of patients experience adequate response. Here the authors find dysregulation of miRNAs in peripheral blood samples from depressed patients after antidepressant treatment, and show that the miRNAs are regulators of psychiatrically relevant signalling pathways.

Juan Pablo Lopez
Laura M. Fiori
Gustavo Turecki
ResearchOpen Access22 May 2017
Nature Communications

Volume: 8, P: 1-12
ACF chromatin-remodeling complex mediates stress-induced depressive-like behavior

Upregulation of the ATP-dependent ACF chromatin-remodeling complex in the NAc is a necessary and causal component for susceptibility to stress-induced depressive behaviors in mice, and this complex is also shown to be upregulated in the NAc of depressed humans.

HaoSheng Sun
Diane M Damez-Werno
Eric J Nestler
Research21 Sept 2015
Nature Medicine

Volume: 21, P: 1146-1153
Genome-wide transcriptional profiling of central amygdala and orbitofrontal cortex during incubation of methamphetamine craving

Hannah M. Cates
Xuan Li
Eric J. Nestler
Research20 Jul 2018
Neuropsychopharmacology

Volume: 43, P: 2426-2434
A surgical orthotopic approach for studying the invasive progression of human bladder cancer

A small laparotomy is carried out, and human cancer cells are implanted into the mouse bladder lumen. This reproduces the pathobiological events of human bladder cancer invasion in mice.

Guadalupe Lorenzatti Hiles
Angelica L. Cates
Mark L. Day
Protocols25 Jan 2019
Nature Protocols

Volume: 14, P: 738-755
Clinical and virologic characteristics of the first 12 patients with coronavirus disease 2019 (COVID-19) in the United States

Detailed clinical and virologic characteristics of the first 12 individuals with COVID-19 in the United States from the US Centers for Disease Control and Prevention.

Stephanie A. Kujawski
Karen K. Wong
Jing Zhang
Research23 Apr 2020
Nature Medicine

Volume: 26, P: 861-868
Blood miR-144-3p: a novel diagnostic and therapeutic tool for depression

Yentl Y. van der Zee
Lars M. T. Eijssen
Orna Issler
Research28 Jul 2022
Molecular Psychiatry

Volume: 27, P: 4536-4549
Complement pathway changes at age 12 are associated with psychotic experiences at age 18 in a longitudinal population-based study: evidence for a role of stress

Melanie Föcking
Sophie Sabherwal
David R. Cotter
ResearchOpen Access11 Jan 2019
Molecular Psychiatry

Volume: 26, P: 524-533
A novel role for E2F3b in regulating cocaine action in the prefrontal cortex

Hannah M. Cates
Rosemary C. Bagot
Eric J. Nestler
Research14 Dec 2018
Neuropsychopharmacology

Volume: 44, P: 776-784
Gastrointestinal stromal tumors (GISTs) arising in uncommon locations: clinicopathologic features and risk assessment of esophageal, colonic, and appendiceal GISTs

Shaomin Hu
Lindsay Alpert
John Hart
Research26 Oct 2021
Modern Pathology

Volume: 35, P: 554-563

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