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Showing 1–7 of 7 results
Advanced filters: Author: Hannes Ausserwöger Clear advanced filters

  • pH is a critical regulator of (bio)chemical processes and therefore tightly regulated in nature. Now, proteins have been shown to possess the functionality to drive pH gradients without requiring energy input or membrane enclosure but through condensation. Protein condensates can drive unique pH gradients that modulate biochemical activity in both living and artificial systems.

    • Hannes Ausserwöger
    • Rob Scrutton
    • Tuomas P. J. Knowles
    ResearchOpen Access
    Nature Chemistry
    P: 1-12

  • Biomolecular phase separation arises from collective molecular interactions and is emerging as a key theme for biological function. Here the authors propose a broadly applicable method to quantify these interactions based on compositional and energetic parameters.

    • Hannes Ausserwöger
    • Ella de Csilléry
    • Tuomas P. J. Knowles
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13

  • In this work the authors describe antimicrobial peptides (AMPs)-driven phase transitions of intracellular nucleic acids, whereby AMPs induce compaction and phase separation of nucleic acids, resulting in their sequestration and eventual cell death.

    • Tomas Sneideris
    • Nadia A. Erkamp
    • Tuomas P. J. Knowles
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • Biomolecular condensates with internal structure allow cells to further organise their processes. In this work the authors investigate how condensates can obtain an internal structure with droplets of dilute phase inside via kinetic, rather than purely thermodynamic driving forces.

    • Nadia A. Erkamp
    • Tomas Sneideris
    • Tuomas P. J. Knowles
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-8

  • Biomolecular condensates form via phase separation of multivalent macromolecules. Phase separation is governed by solubility whereas multivalence drives percolation, also known as gelation. The authors in this work identify the distinct energy and length scales that influence phase separation versus percolation.

    • Mrityunjoy Kar
    • Laura T. Vogel
    • Rohit V. Pappu
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-21

  • While antibodies have a remarkable track record in therapeutics, achieving sufficient specificity remains an issue. This Review discusses the physicochemistry of non-specificity, with a focus on surface patches as a key challenge, and outlines future opportunities to improve protein binding.

    • Hannes Ausserwöger
    • Matthias M. Schneider
    • Nikolai Lorenzen
    Reviews
    Nature Reviews Chemistry
    Volume: 6, P: 844-861