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Showing 1–9 of 9 results
Advanced filters: Author: Hannes C. A. Drexler Clear advanced filters

  • Talin is a well-known regulator of cell adhesion and intracellular force transmission in animals. Here, the authors demonstrate that talin’s mechanical function is evolutionarily conserved and already established in unicellular eukaryotes.

    • Srishti Rangarajan
    • Lena Espeter
    • Carsten Grashoff
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • Influenza A virus replication relies on host cell-derived ubiquitination of the viral polymerase. Here, Günl et al. show that site-specific ubiquitination of PB1-K578 is acquired during infection and facilitates spatiotemporal control of polymerase dimerization and NP binding.

    • Franziska Günl
    • Tim Krischuns
    • Linda Brunotte
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-19

  • Human papillomavirus (HPV) coopts mitosis for nuclear entry by tethering the viral DNA to mitotic chromosomes, a process facilitated by the viral minor capsid protein L2. Here, Rizzato et al. show that L2 contains conserved phosphorylation motifs within the chromosome-binding region and provide evidence that host master mitotic kinases CDK1 and PLK1 sequentially mediate phosphorylation of L2 at mitosis onset to allow timely tethering of viral DNA to mitotic chromosomes.

    • Matteo Rizzato
    • Fuxiang Mao
    • Mario Schelhaas
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • How pluripotency transcription factors regulate the cellular architecture and energetics has remained largely unknown. Here the authors identify Lima1 as a key effector that mediates the pluripotency control of membrane dynamics and cellular metabolism.

    • Binyamin Duethorn
    • Fabian Groll
    • Ivan Bedzhov
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-19

  • The sprouting activity of filopodia emerging from endothelial sprouting cells needs to be compensated for in mature stable vessels. Adams and colleagues find that sprouting cells in mouse retinal vasculature show high VEGF uptake and VEGF receptor turnover, both essential for sprouting. These are inhibited by an aPKC-mediated decrease in VEGF receptor endocytosis in mature vessels, through a mechanism implicating clathrin-associated proteins, the transmembrane protein ephrin-B2 and the polarity factor PAR-3.

    • Masanori Nakayama
    • Akiko Nakayama
    • Ralf H. Adams
    Research
    Nature Cell Biology
    Volume: 15, P: 249-260

  • Oct4 cannot be replaced by other members of the same family of transcription factors to induce reprogramming. By comparing the structure of the POU family domain of Oct4 complexed to DNA with that of others, Schöler and colleagues identify an α-helix that is exposed on the surface of Oct4 and provides an interaction platform to recruit epigenetic modifiers to Oct4 targets. Mutations abolishing this helix suppress the reprogramming properties of Oct4.

    • Daniel Esch
    • Juha Vahokoski
    • Hans R. Schöler
    Research
    Nature Cell Biology
    Volume: 15, P: 295-301