Nature Search

Structure of HBP, a multifunctional protein with a serine proteinase fold

The structure of human heparin binding protein reveals that the serine proteinase fold has been used as a scaffold for a multifunctional protein with antibacterial activity, monocyte and T-cell activating properties and endotoxin and heparin binding capacity.

Lars Fogh Iversen
Jette Sandholm Kastrup
Ingrid Kjøller Larsen
Correspondence01 Apr 1997
Nature Structural Biology

Volume: 4, P: 265-268
Impact of groundwater nitrogen legacy on water quality

National and international policies have aimed to protect the quality of freshwater by mitigating agricultural nitrogen emissions. However, the nitrogen legacy in groundwater must be accounted for when mitigating the impacts of nitrogen in watersheds.

Xiaochen Liu
Arthur H. W. Beusen
Alexander F. Bouwman
ResearchOpen Access12 Jun 2024
Nature Sustainability

Volume: 7, P: 891-900
Antigen-specific Fab profiling achieves molecular-resolution analysis of human autoantibody repertoires in rheumatoid arthritis

Although many autoimmune diseases are characterized by the presence of autoantibodies, complete characterisation of autoantibody repertoires is lacking. Here, the authors introduce an autoantigen-specific Fab profiling method to show that the autoantibody repertoire in rheumatoid arthritis is diverse yet dominated only by a few clones.

Eva Maria Stork
Danique M. H. van Rijswijck
Albert Bondt
ResearchOpen Access10 Apr 2024
Nature Communications

Volume: 15, P: 1-12
Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017

Fine-scale geospatial mapping of overweight and wasting (two components of the double burden of malnutrition) in 105 LMICs shows that overweight has increased from 5.2% in 2000 to 6.0% in children under 5 in 2017. Although overall wasting decreased over the same period, most countries are not on track to meet the World Health Organization’s Global Nutrition Target of <5% in over half of LMICs by 2025.

Damaris K. Kinyoki
Jennifer M. Ross
Simon I. Hay
ResearchOpen Access20 Apr 2020
Nature Medicine

Volume: 26, P: 750-759
Validation of climate model-inferred regional temperature change for late-glacial Europe

Comparison of climate model hindcasts with proxy data is essential to improve model reliability, yet standardized palaeoclimate data sets are lacking. Here, Heiri et al. compare chironomid-based palaeotemperature records with the ECHAM-4 atmospheric general circulation model, showing excellent agreement.

Oliver Heiri
Stephen J. Brooks
André F. Lotter
Research11 Sept 2014
Nature Communications

Volume: 5, P: 1-7
Genetic control of lipoprotein(a) concentrations is different in Africans and Caucasians

Michael Scholz
Hans-Georg Kraft
Gerd Utermann
Research30 Mar 1999
European Journal of Human Genetics

Volume: 7, P: 169-178
An mTORC1-mediated negative feedback loop constrains amino acid-induced FLCN-Rag activation in renal cells with TSC2 loss

The MiT/TFE transcription factors are phosphorylated and inactivated by mTORC1. Here, authors demonstrate that TFEB is paradoxically hypophosphorylated and activated in cells with TSC2 loss due to impaired lysosomal recruitment of the FLCN:FNIP2 complex in renal cells.

Kaushal Asrani
Juhyung Woo
Tamara L. Lotan
ResearchOpen Access10 Nov 2022
Nature Communications

Volume: 13, P: 1-15
Concentrations of the atherogenic Lp(a) are elevated in familial hypercholesterolaemia: a sib pair and family analysis

Arno Lingenhel
Hans Georg Kraft
Gerd Utermann
Research12 Mar 1998
European Journal of Human Genetics

Volume: 6, P: 50-60
Author Correction: Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017

Damaris K. Kinyoki
Jennifer M. Ross
Simon I. Hay
Amendments and CorrectionsOpen Access02 Jul 2020
Nature Medicine

Volume: 26, P: 1308
Beneficial effects of elafibranor on NASH in E3L.CETP mice and differences between mice and men

Anita M. van den Hoek
Lars Verschuren
Hans M. G. Princen
ResearchOpen Access03 Mar 2021
Scientific Reports

Volume: 11, P: 1-14
Hallucinations in borderline personality disorder: Prevalence, characteristics and associations with comorbid symptoms and disorders

Maria B. A. Niemantsverdriet
Christina W. Slotema
Mark van der Gaag
ResearchOpen Access24 Oct 2017
Scientific Reports

Volume: 7, P: 1-8
Meta-analysis of probability estimates of worldwide variation of CYP2D6 and CYP2C19

Anne B. Koopmans
Mario H. Braakman
Peter N. van Harten
ReviewsOpen Access24 Feb 2021
Translational Psychiatry

Volume: 11, P: 1-16

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