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Showing 1–6 of 6 results
Advanced filters: Author: Hanseul Yang Clear advanced filters

  • Recovery for mammalian retinal degeneration is limited by a lack of Müller glia (MG)-mediated regeneration. Here authors show blocking Prox1 accumulation and intercellular transfer from retinal neurons enables MG reprogramming of retinal progenitor cells, promotes retinal neuron regeneration, and delays vision loss.

    • Eun Jung Lee
    • Museong Kim
    • Jin Woo Kim
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17

  • Aberrant crosstalk between cancer stem cells and their microenvironment triggers angiogenesis and TGFβ signalling, creating conditions that are conducive for hijacking leptin and leptin receptor signalling, which in turn launches downstream PI3K–AKT–mTOR signalling during the benign-to-malignant transition.

    • Shaopeng Yuan
    • Katherine S. Stewart
    • Elaine Fuchs
    ResearchOpen Access
    Nature
    Volume: 612, P: 555-563

  • Therapies and vaccines for COVID-19, caused by the SARS-CoV-2 viral pandemic, are urgently needed. Here the authors establish and screen an antibody library from a convalescent COVID-19 patient to isolate a neutralizing antibody with the ability to reduce viral titer and alleviate symptoms in ferret, hamster, and rhesus monkey infection models.

    • Cheolmin Kim
    • Dong-Kyun Ryu
    • Soo-Young Lee
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10

  • An analysis of mouse skin reveals that super-enhancers are critical to identity, lineage commitment and plasticity of adult stem cells; dynamic super-enhancer remodelling in new niches is dependent on the levels of pioneer transcription factor SOX9, which is identified as a key regulator of super-enhancer chromatin for hair follicle stem cells.

    • Rene C. Adam
    • Hanseul Yang
    • Elaine Fuchs
    Research
    Nature
    Volume: 521, P: 366-370

  • Kim et al. conducted single-cell RNA sequencing to determine the transcriptome profiles of human nail units using polydactyly specimens to demonstrate mesenchymal and epithelial cell populations, characterized by RSPO4 and SPINK6 respectively. RSPO4 + onychofibroblasts localized with LGR6 + nail matrix, leading to WNT/ β-catenin activation and suggesting a role for onychofibroblasts in onychomatricoma pathogenesis.

    • Hyun Je Kim
    • Joon Ho Shim
    • Dongyoun Lee
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-13