Nature Search

Spatiotemporally controlled restoration of GAS6 signaling via mRNA therapy promotes scarless healing in preclinical models

Deep skin injuries often lead to scarring. Here, the authors show that restoring GAS6 via an mRNA-hydrogel platform enhances wound healing and reduces fibrosis in preclinical models.

Yan He
Kai Ye
Chenggang Yi
ResearchOpen Access25 Feb 2026
Nature Communications

Volume: 17, P: 1-19
CRISPR-free RNA base editing mediated PTC-readthrough restores hearing in mice with Otof nonsense mutation

Nonsense mutations in OTOF cause hereditary deafness. RESTART v3 achieves efficient, precise readthrough at Otof c.1315 C > T (p.R439*) sites, reinstating arginine to yield full-length, functional otoferlin, markedly restoring hearing in mice and showing strong promise for clinical translation.

Hanxiao Sun
Qi Teng
Ke Liu
ResearchOpen Access06 Dec 2025
Nature Communications

Volume: 17, P: 1-16
Single-nucleus multi-omics analysis of mouse small-intestinal Lgr5+ cell populations reveals Foxa3-induced Paneth cell-lineage differentiation

Employing single-cell multi-omics and organoid technology, lineage specification and early fate determination of small intestinal stem cells is more deeply revealed, showing that Foxa3 influences Paneth cell differentiation by regulating Peroxisome-Proliferator-Activated Receptors (PPARs).

Xinran Deng
Shenfei Sun
Ning Jiang
ResearchOpen Access21 Feb 2026
Communications Biology

Volume: 9, P: 1-16
Mild and ultrafast GLORI enables absolute quantification of m⁶A methylome from low-input samples

This work introduces GLORI 2.0 and 3.0, enabling sensitive m⁶A quantification from RNA inputs as low as a few hundred cells.

Hanxiao Sun
Bo Lu
Chengqi Yi
Research05 May 2025
Nature Methods

Volume: 22, P: 1226-1236
Marginal zone B cells mediate humoral immunity in vaccine-induced versus naturally acquired immunity against SARS-CoV-2

Jie Shu
Jiameng Yao
Huiming Sheng
ResearchOpen Access22 Feb 2026
Scientific Reports

Volume: 16, P: 1-15
Nuclear m⁶A modification regulates satellite transcription and chromosome segregation

Profiling nuclear N⁶-methyladenosine (m⁶A) modifications revealed enrichment of m⁶A on nuclear RNAs derived from chromosome pericentromeric γ satellite DNA II (GSATII), which regulates GSATII transcription and influences chromosome segregation during mitosis.

Chenyang Huang
Xiao Shu
Jianzhao Liu
Research22 May 2025
Nature Chemical Biology

P: 1-13
m⁶Am-seq reveals the dynamic m⁶Am methylation in the human transcriptome

m⁶Am is a dynamic and reversible RNA modification found on the mRNA cap. Here the authors report m⁶Am-seq to directly distinguish m⁶Am from m⁶A and identify functional methylation sites.

Hanxiao Sun
Kai Li
Chengqi Yi
ResearchOpen Access06 Aug 2021
Nature Communications

Volume: 12, P: 1-12
Absolute quantification of single-base m⁶A methylation in the mammalian transcriptome using GLORI

The m⁶A modification is mapped transcriptome-wide at single-base resolution in mammalian cells.

Cong Liu
Hanxiao Sun
Jing Wang
Research27 Oct 2022
Nature Biotechnology

Volume: 41, P: 355-366
Activation of DR3 signaling causes loss of ILC3s and exacerbates intestinal inflammation

Group 3 innate lymphoid cells (ILC3s) have important functions in inflammatory bowel disease. Here, the authors show that TL1A/DR3 signalling stimulates ILC3s to produce GM-CSF, thereby recruiting inflammatory cells, which results in subsequent IL-23-dependent loss of ILC3s and further intestinal inflammation.

Jingyu Li
Wenli Shi
Ju Qiu
ResearchOpen Access29 Jul 2019
Nature Communications

Volume: 10, P: 1-15
Near-cognate tRNAs increase the efficiency and precision of pseudouridine-mediated readthrough of premature termination codons

Disease-related premature stop codons are efficiently corrected by harnessing near-cognate tRNAs.

Nan Luo
Qiang Huang
Chengqi Yi
Research06 Mar 2024
Nature Biotechnology

Volume: 43, P: 114-123
Regulation and functions of non-m⁶A mRNA modifications

Nucleobase modifications are prevalent in eukaryotic mRNA and are broadly required for post-transcriptional gene regulation. The most studied mRNA modification is N⁶-methyladenosine (m⁶A), yet various other modifications are now being identified and studied. This Review discusses the emerging mechanisms and roles of these non-m⁶A modifications.

Hanxiao Sun
Kai Li
Chengqi Yi
Reviews27 Jun 2023
Nature Reviews Molecular Cell Biology

Volume: 24, P: 714-731
Engineered model of heart tissue repair for exploring fibrotic processes and therapeutic interventions

Engineered human models of hearts are needed to study pathology and repair. Here, the authors develop a model which replicates the phased remodelling process. The model is then used to study signalling pathway modulators for their therapeutic potential in a mini-repair model.

Pengcheng Yang
Lihang Zhu
Donghui Zhang
ResearchOpen Access12 Sept 2024
Nature Communications

Volume: 15, P: 1-21
Crystal Structures of Wolbachia CidA and CidB Reveal Determinants of Bacteria-induced Cytoplasmic Incompatibility and Rescue

Wolbachia induced cytoplasmic incompatibility (CI) is caused by linked pairs of genes named cifA and cifB. Here, authors show that the residues at interfaces of the CidA-CidB complex is crucial for their binding and contribute to the diversity of CI.

Haofeng Wang
Yunjie Xiao
Haitao Yang
ResearchOpen Access25 Mar 2022
Nature Communications

Volume: 13, P: 1-11
Atorvastatin suppresses high-risk colorectal adenomas via reprogramming of lipid metabolism and Inhibition of stemness

Wentong Chen
Mengxiao Ge
Zhongguang Luo
ResearchOpen Access27 Dec 2025
Scientific Reports

Volume: 16, P: 1-15
Tissue signals imprint Aiolos expression in ILC2s to modulate type 2 immunity

Jinxin Qiu
Jingjing Zhang
Ju Qiu
ResearchOpen Access04 Aug 2021
Mucosal Immunology

Volume: 14, P: 1306-1322
Biodegradation of highly crystallized poly(ethylene terephthalate) through cell surface codisplay of bacterial PETase and hydrophobin

High-crystallinity poly(ethylene terephthalate) is a major recycling challenge. Here, the authors show an engineered whole-cell biocatalyst showing adhesive hydrophobin and PETase on the surface of cells, for biodegradation of PET.

Zhuozhi Chen
Rongdi Duan
Zefang Wang
ResearchOpen Access21 Nov 2022
Nature Communications

Volume: 13, P: 1-17
Setd2 supports GATA3⁺ST2⁺ thymic-derived Treg cells and suppresses intestinal inflammation

Treg cells can be functionally altered by epigenetic modulators. Here the authors show that the histone H3K36 methyltransferase Setd2 is important for the survival of Treg cells and for the regulation of IL-33 mediated Th2 responses in mice and SETD2 expression is increased in Treg cells from human colorectal cancer tissue.

Zhaoyun Ding
Ting Cai
Ju Qiu
ResearchOpen Access03 Dec 2022
Nature Communications

Volume: 13, P: 1-19
All-optical field-free three-dimensional orientation of asymmetric-top molecules

Alignment and orientation of the molecules allows studying the photon-molecule interactions in greater detail. Here the authors demonstrate the three-dimensional orientation of SO₂ molecules in using COLTRIMS and orthogonally polarized laser pulses but in the absence of DC field.

Kang Lin
Ilia Tutunnikov
Jian Wu
ResearchOpen Access03 Dec 2018
Nature Communications

Volume: 9, P: 1-9
Cyclodextrin-Based Metal-Organic Nanotube as Fluorescent Probe for Selective Turn-On Detection of Hydrogen Sulfide in Living Cells Based on H₂S-Involved Coordination Mechanism

Xuelian Xin
Jingxin Wang
Daofeng Sun
ResearchOpen Access25 Feb 2016
Scientific Reports

Volume: 6, P: 1-9
Electron-nuclear correlated multiphoton-route to Rydberg fragments of molecules

Rydberg atoms can be created from photoexcitation of molecules using intense ultrafast laser pulses. Here the authors use a coincidence detection of electrons, ion and excited Rydberg atoms and their energy sharing to reveal the general mechanism of Rydberg state excitation in a dissociating H₂ molecule.

Wenbin Zhang
Xiaochun Gong
Jian Wu
ResearchOpen Access14 Feb 2019
Nature Communications

Volume: 10, P: 1-8
M2 macrophages independently promote beige adipogenesis via blocking adipocyte Ets1

Adipose beiging is a positive biological change, which is often thought to be primarily sympathetically induced. Here, the authors show that M2 macrophages can independently promote beige adipogenesis, further revealing the adipocyte transcription factor Ets1 as a negative regulator of this process.

Suyang Wu
Chen Qiu
Xiao Han
ResearchOpen Access22 Feb 2024
Nature Communications

Volume: 15, P: 1-17
GLORI for absolute quantification of transcriptome-wide m⁶A at single-base resolution

The formation and functional relevance of N⁶-methyladenosine sites are key unanswered questions in the field of RNA biology. The protocol describes an unbiased sequencing-based method for the characterization of the global distribution and stoichiometry of N⁶-methyladenosine sites.

Weiguo Shen
Hanxiao Sun
Chengqi Yi
Protocols22 Jan 2024
Nature Protocols

Volume: 19, P: 1252-1287
Integrative bioinformatics approach identifies novel drug targets for hyperaldosteronism, with a focus on SHMT1 as a promising therapeutic candidate

Minyue Jia
Liya Lin
Xiaoxiao Song
ResearchOpen Access11 Jan 2025
Scientific Reports

Volume: 15, P: 1-21
Validation of the BD FACSPresto system for the measurement of CD4 T-lymphocytes and hemoglobin concentration in HIV-negative and HIV-positive subjects

Xiaofan Lu
Hanxiao Sun
Zhaoqin Zhu
ResearchOpen Access11 Nov 2020
Scientific Reports

Volume: 10, P: 1-11
Comparative population genomics dissects the genetic basis of seven domestication traits in jujube

Mingxin Guo
Zhongren Zhang
Xusheng Zhao
ResearchOpen Access01 Jun 2020
Horticulture Research

Volume: 7, P: 1-14
Using detrital zircon to reconstruct Neoproterozoic crustal thickness variation in the northwestern margin of the Yangtze Block

Qiang Gu
Fengcun Xing
Jinchi Yi
ResearchOpen Access24 Apr 2025
Scientific Reports

Volume: 15, P: 1-18
Study on the promotion of lymphocytes in patients with COVID-19 by broad-spectrum chemokine receptor inhibitor vMIP-II and its Mechanism of signal transmission in vitro

Shiyu Li
Shuting Liu
Hanxiao Sun
ResearchOpen Access02 Mar 2021
Signal Transduction and Targeted Therapy

Volume: 6, P: 1-3
Heritable variation at the chromosome 21 gene ERG is associated with acute lymphoblastic leukemia risk in children with and without Down syndrome

Adam J. de Smith
Kyle M. Walsh
Joseph L. Wiemels
ResearchOpen Access11 Jul 2019
Leukemia

Volume: 33, P: 2746-2751
Differential immune responses in pregnant patients recovered from COVID-19

Ge Chen
Yiming Zhang
Kezhen Li
ResearchOpen Access29 Jul 2021
Signal Transduction and Targeted Therapy

Volume: 6, P: 1-15
Emerging roles of ILC2s in antitumor immunity

Zhao Li
Hanxiao Sun
Ju Qiu
Correspondence02 Sept 2022
Cellular & Molecular Immunology

Volume: 19, P: 1311-1313
Pan-cancer transcriptomic analysis identified six classes of immunosenescence genes revealed molecular links between aging, immune system and cancer

Xinyue Wang
Shuang Guo
Shangwei Ning
Research17 Feb 2023
Genes & Immunity

Volume: 24, P: 81-91
Cap-specific, terminal N⁶-methylation by a mammalian m⁶Am methyltransferase

Hanxiao Sun
Meiling Zhang
Chengqi Yi
CorrespondenceOpen Access28 Nov 2018
Cell Research

Volume: 29, P: 80-82
SRSF1 promotes the inclusion of exon 3 of SRA1 and the invasion of hepatocellular carcinoma cells by interacting with exon 3 of SRA1pre-mRNA

Sijia Lei
Bin Zhang
Feng Wang
ResearchOpen Access19 May 2021
Cell Death Discovery

Volume: 7, P: 1-15
The UL16 protein of HSV-1 promotes the metabolism of cell mitochondria by binding to ANT2 protein

Shiyu Li
Shuting Liu
Hanxiao Sun
ResearchOpen Access07 Jul 2021
Scientific Reports

Volume: 11, P: 1-11
The m⁶A methylome of SARS-CoV-2 in host cells

Jun’e Liu
Yan-Peng Xu
Cheng-Feng Qin
ResearchOpen Access28 Jan 2021
Cell Research

Volume: 31, P: 404-414
Berberine-releasing electrospun scaffold induces osteogenic differentiation of DPSCs and accelerates bone repair

Lan Ma
Yijun Yu
Leiying Miao
ResearchOpen Access13 Jan 2021
Scientific Reports

Volume: 11, P: 1-12
SIRT2 functions as a histone delactylase and inhibits the proliferation and migration of neuroblastoma cells

Hanxiao Zu
Chang Li
Xi Mo
CorrespondenceOpen Access07 Jun 2022
Cell Discovery

Volume: 8, P: 1-5
PPA1 promotes adipogenesis by regulating the stability of C/EBPs

Yangyang Wu
Yue Sun
Xiao Han
Research18 May 2024
Cell Death & Differentiation

Volume: 31, P: 1044-1056
Group 2 innate lymphoid cells can engulf and destroy bacteria

Yiran Yang
Yan Li
Sun Ying
Correspondence14 Sept 2021
Cellular & Molecular Immunology

Volume: 18, P: 2569-2571
Lentinan confers protection against type 1 diabetes by inducing regulatory T cell in spontaneous non-obese diabetic mice

Tijun Wu
Zhi Cai
Xiao Han
ResearchOpen Access08 Apr 2023
Nutrition & Diabetes

Volume: 13, P: 1-8
Domain-specific expression of meristematic genes is defined by the LITTLE ZIPPER protein DTM in tomato

Qian Xu et al. show that shoot apical meristem activity in tomato is maintained by a LITTLE ZIPPER protein known as DTM. This protein negatively regulates a class of HD-ZIP III transcription factors, ultimately maintaining stem cell homeostasis.

Qian Xu
Rong Li
Han Xiao
ResearchOpen Access23 Apr 2019
Communications Biology

Volume: 2, P: 1-14
Ets-1 deficiency alleviates nonalcoholic steatohepatitis via weakening TGF-β1 signaling-mediated hepatocyte apoptosis

Dechen Liu
Kai Wang
Xiao Han
ResearchOpen Access12 Jun 2019
Cell Death & Disease

Volume: 10, P: 1-14
A Presenilin/Notch1 pathway regulated by miR-375, miR-30a, and miR-34a mediates glucotoxicity induced-pancreatic beta cell apoptosis

Yating Li
Tao Zhang
Xiao Han
ResearchOpen Access02 Nov 2016
Scientific Reports

Volume: 6, P: 1-12
The BCL2 major breakpoint region (mbr) regulates gene expression

C Ma
J Zhang
Y Sun
Research23 Oct 2006
Oncogene

Volume: 26, P: 2649-2657

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