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Communications Biology (1)

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SIRT5-mediated desuccinylation of MTHFD2 enhances chemoresistance in breast cancer cells by reducing therapy-induced senescence

The mechanism by which SIRT5 mediates desuccinylation of MTHFD2 at lysine 44 reveals that SIRT5 influences therapy-induced senescence and chemoresistance in breast cancer cells through regulation of MTHFD2 desuccinylation.

Zhang Xianhong
Gao Yue
Ni Ting
ResearchOpen Access20 Oct 2025
Communications Biology

Volume: 8, P: 1-20

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SIRT5-mediated desuccinylation of MTHFD2 enhances chemoresistance in breast cancer cells by reducing therapy-induced senescence

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