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Showing 1–2 of 2 results
Advanced filters: Author: Haonan Huo Clear advanced filters

  • Cryoprotectants are needed for the storage of lipid nanoparticles (LNPs). Here, the authors report on a study which shows that freezing can be harnessed to reformulate LNPs in a way that both preserves their integrity and boosts mRNA delivery after sub-zero storage by increasing endosomal escape.

    • Xingdi Cheng
    • Xia Zheng
    • Jianjun Wang
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12

  • The instability of lipid nanoparticles during nebulization hinders inhaled mRNA vaccines. Here, the authors report on a charge-assisted stabilization strategy using a peptide-lipid conjugate to improve lipid nanoparticle stability, enabling mRNA-based mucosal vaccines for SARS-CoV-2 and lung cancer.

    • Shuai Liu
    • Yixing Wen
    • Xueguang Lu
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18