The ability to differentiate human pluripotent stem cells (hPSCs) into insulin producing cells holds potential for diabetes treatments, but many of these approaches lack the complexity needed for in vitro disease modeling. Here they develop an hPSC-derived islet spheroid system, offering an experimental model to study pancreatic budding and islet morphogenesis with human cells.
- Jia Zhao
- Shenghui Liang
- Timothy J. Kieffer
