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Showing 1–6 of 6 results
Advanced filters: Author: Harald Janovjak Clear advanced filters

  • The combination of a light-activated receptor tyrosine kinase and a fluorescent MAPK/ERK reporter results in the development of an optogenetics-based cell screening method to identify small-molecule inhibitors of RTK signaling.

    • Álvaro Inglés-Prieto
    • Eva Reichhart
    • Harald Janovjak
    Research
    Nature Chemical Biology
    Volume: 11, P: 952-954

  • Designing optogenetically functionalized G protein-coupled receptors (optoXRs) to mimic endogenous signaling in vivo is challenging. Here, the authors optimize the design of optoXRs by considering evolutionary conserved protein interactions, and they employ this approach in fruit flies.

    • Fangmin Zhou
    • Alexandra-Madelaine Tichy
    • Peter Soba
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-18

  • G-protein coupled receptors (GPCRs) represent the largest receptor family and are prime drug targets, but many orphan GPCRs are poorly characterized. Here authors engineer human orphan GPCRs to be activated by light which allows studying the receptors ligand identity and downstream signaling.

    • Maurizio Morri
    • Inmaculada Sanchez-Romero
    • Harald Janovjak
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10

  • A genetically encoded FRET-based optical sensor generated from a computational design approach can monitor hippocampal glycine levels in brain tissue to determine differences between spines and shafts and changes induced by high- and low-frequency stimulation.

    • William H. Zhang
    • Michel K. Herde
    • Christian Henneberger
    Research
    Nature Chemical Biology
    Volume: 14, P: 861-869

  • This Technical Report describes light-activatable metabotropic glutamate receptors based on synthetic photoswitchable tethered ligands, and demonstrates optogenetic control of G protein–coupled receptor activity in neurons in vivo and ex vivo.

    • Joshua Levitz
    • Carlos Pantoja
    • Ehud Y Isacoff
    Research
    Nature Neuroscience
    Volume: 16, P: 507-516