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Showing 1–50 of 56 results

Advanced filters: Author: Harpreet Singh Clear advanced filters

High sensitivity pressure and temperature quantum sensing in pentacene-doped p-terphenyl single crystals

Molecular systems featuring a spin-optical interface offer a promising platform for quantum sensing, thanks to their low-cost synthesis and tunability. Here the authors use pentacene-doped molecular crystals for pressure and temperature sensing with improved temperature and record pressure sensitivities.

Harpreet Singh
Noella D’Souza
Ashok Ajoy
ResearchOpen Access26 Nov 2025
Nature Communications

Volume: 16, P: 1-8
Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Cecilia Anza-Ramirez
J. Jaime Miranda
Yves Miel H. Zuniga
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-36
Leveraging omic features with F3UTER enables identification of unannotated 3’UTRs for synaptic genes

3’ untranslated regions (3’UTRs) play a crucial role in regulating gene expression, but our 3’UTR catalogue is incomplete. Here, the authors develop a machine learning-based framework to predict previously unannotated 3’UTRs in 39 human tissues.

Siddharth Sethi
David Zhang
Juan A. Botia
ResearchOpen Access27 Apr 2022
Nature Communications

Volume: 13, P: 1-15
Comparison of dual therapies for hypertension treatment in India: a randomized clinical trial

To address an evidence gap for the efficacy of hypertension therapy using dual drug combinations in patients of South Asian origin, a randomized clinical trial conducted in India found that three types of dual drug combinations, each administered in a single pill, had similarly large effects on reducing blood pressure.

Dorairaj Prabhakaran
Ambuj Roy
Neil R. Poulter
ResearchOpen Access25 Jul 2025
Nature Medicine

Volume: 31, P: 3169-3175
Functional large-conductance calcium and voltage-gated potassium channels in extracellular vesicles act as gatekeepers of structural and functional integrity

Extracellular vesicles secreted by cells play a crucial role in cellular communication. Here, the authors identify a functional BK channel in extracellular vesicle membranes and establish its role in preserving vesicle integrity, K+ homeostasis, and physiological function.

Shridhar Sanghvi
Divya Sridharan
Harpreet Singh
ResearchOpen Access02 Jan 2025
Nature Communications

Volume: 16, P: 1-11
Identification and Characterization of a Bacterial Homolog of Chloride Intracellular Channel (CLIC) Protein

Shubha Gururaja Rao
Devasena Ponnalagu
Harpreet Singh
ResearchOpen Access17 Aug 2017
Scientific Reports

Volume: 7, P: 1-13
Refining neoadjuvant therapy clinical trial design for muscle-invasive bladder cancer before cystectomy: a joint US Food and Drug Administration and Bladder Cancer Advocacy Network workshop

Trials evaluating novel therapies in the neoadjuvant setting must have clearly defined study elements and appropriately selected end points to ensure the applicability of the trial and enable interpretation of the study results. In this Perspectives, the authors describe the findings of a public workshop jointly sponsored by the US Food and Drug Administration and the Bladder Cancer Advocacy Network, which discussed key elements and end points when designing trials of neoadjuvant therapy for muscle-invasive bladder cancer.

Elaine Chang
Andrea B. Apolo
Matthew D. Galsky
Reviews10 Sept 2021
Nature Reviews Urology

Volume: 19, P: 37-46
Mitophagy mitigates mitochondrial fatty acid β-oxidation deficient cardiomyopathy

The heart relies on fatty acid oxidation as its main energy source. Here they show that impaired fatty acid metabolism disrupts mitophagy in the heart and that enhancing mitophagy via USP30 inhibition can restore heart function in models of fatty acid oxidation deficiency.

Nuo Sun
Hayley Barta
Toren Finkel
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-15
Autologous T cell therapy for PRAME⁺ advanced solid tumors in HLA-A*02⁺ patients: a phase 1 trial

In a non-prespecified interim analysis of a phase 1 trial, autologous PRAME-directed TCR T cell therapy was safe and elicited durable responses in patients with recurrent and/or treatment-refractory PRAME⁺ advanced solid tumors, including melanoma and synovial sarcoma.

Martin Wermke
Dejka M. Araujo
Cedrik M. Britten
ResearchOpen Access09 Apr 2025
Nature Medicine

Volume: 31, P: 2365-2374
Multipeptide immune response to cancer vaccine IMA901 after single-dose cyclophosphamide associates with longer patient survival

In this issue, Walter et al. report the results of two clinical trials of a new therapeutic vaccine, IMA901, for the treatment of renal cell carcinoma (RCC). IMA901 consists of ten tumor-associated peptides identified as naturally presented T cell epitopes in RCC, and the authors show longer overall survival in subjects with immune responses to multiple vaccine peptides and identify serum and cellular biomarkers that may help predict overall survival in future studies of the vaccine.

Steffen Walter
Toni Weinschenk
Harpreet Singh-Jasuja
Research29 Jul 2012
Nature Medicine

Volume: 18, P: 1254-1261
Encorafenib, cetuximab and chemotherapy in BRAF-mutant colorectal cancer: a randomized phase 3 trial

As presented at the 2025 ASCO GI Cancers Symposium: in the phase 3 BREAKWATER trial, patients with previously untreated BRAF V600E metastatic colorectal cancer received the BRAF inhibitor encorafenib, the anti-EGFR monoclonal antibody cetuximab and chemotherapy mFOLFOX6 versus investigator’s choice of chemotherapy with or without bevacizumab, leading to an improved objective response rate, with the dual primary endpoint of progression free survival still maturing.

Scott Kopetz
Takayuki Yoshino
Josep Tabernero
ResearchOpen Access25 Jan 2025
Nature Medicine

Volume: 31, P: 901-908
Superconductivity in metallic twisted bilayer graphene stabilized by WSe₂

Placing a single layer of tungsten diselenide in contact with twisted bilayer graphene enables superconductivity even for non-magic twist angles where insulating behavior is absent.

Harpreet Singh Arora
Robert Polski
Stevan Nadj-Perge
Research15 Jul 2020
Nature

Volume: 583, P: 379-384
Molecular profiling of BRAF-V600E-mutant metastatic colorectal cancer in the phase 3 BEACON CRC trial

Prespecified exploratory genomic and transcriptomic profiling of tumor tissues and circulating tumor DNA from patients with BRAF-V600E-mutant metastatic colorectal cancer who participated in the phase 3 BEACON CRC trial identifies biomarkers of response and mechanisms of acquired resistance to treatment with the BRAF inhibitor encorafenib plus the anti-EGFR antibody cetuximab, with or without the MEK inhibitor binimetinib.

Scott Kopetz
Danielle A. Murphy
Josep Tabernero
ResearchOpen Access23 Sept 2024
Nature Medicine

Volume: 30, P: 3261-3271
Author Correction: Autologous T cell therapy for PRAME⁺ advanced solid tumors in HLA-A*02⁺ patients: a phase 1 trial

Martin Wermke
Dejka M. Araujo
Cedrik M. Britten
Amendments and CorrectionsOpen Access29 Apr 2025
Nature Medicine

Volume: 31, P: 2453
A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury

Protein kinases have emerged as critical regulators of disease pathogenesis. Here, the authors have utilized kinome-wide screening approaches to reveal a pathogenic role of CDKL5 kinase in acute kidney injury, which is dependent on suppression of a SOX9-associated transcriptional network.

Ji Young Kim
Yuntao Bai
Navjot Singh Pabla
ResearchOpen Access21 Apr 2020
Nature Communications

Volume: 11, P: 1-15
Approvals in 2019: international review and a new agnostic molecular entity

In 2019, the FDA Oncology Center of Excellence (OCE) approved 11 new drugs and biologic agents, 30 supplemental drug and biologic applications, and four biosimilar applications in oncology. These included two landmark approvals involving collaboration among international regulators as part of OCE Project Orbis, as well as the approval of three novel antibody–drug conjugates.

Harpreet Singh
Gideon Blumenthal
Richard Pazdur
Comments & Opinion11 Feb 2020
Nature Reviews Clinical Oncology

Volume: 17, P: 130-131
Design & development of customizable web API for interoperability of antimicrobial resistance data

Jasleen Kaur
Jasmine Kaur
Harpreet Singh
ResearchOpen Access27 May 2021
Scientific Reports

Volume: 11, P: 1-10
SLTChemDB: A database of chemical compounds present in Smokeless tobacco products

Jasmine Kaur
Arun Sharma
Harpreet Singh
ResearchOpen Access09 May 2019
Scientific Reports

Volume: 9, P: 1-8
Optically Graded Ultra Dark Absorber for Visible and Near-infrared Wavelength Range

Prabhat K. Agnihotri
Viney Ghai
Harpreet Singh
ResearchOpen Access17 Aug 2018
Scientific Reports

Volume: 8, P: 1-6
Novel biomarkers of bronchopulmonary dysplasia and bronchopulmonary dysplasia-associated pulmonary hypertension

Mitali Sahni
Bettie Yeboah
Vineet Bhandari
Research18 Aug 2020
Journal of Perinatology

Volume: 40, P: 1634-1643
Correlation-driven topological phases in magic-angle twisted bilayer graphene

Correlation-driven topological phases with different Chern numbers are observed in magic-angle twisted bilayer graphene in modest magnetic fields, indicating that strong electronic interactions can lead to topologically non-trivial phases.

Youngjoon Choi
Hyunjin Kim
Stevan Nadj-Perge
Research18 Jan 2021
Nature

Volume: 589, P: 536-541
PEPlife: A Repository of the Half-life of Peptides

Deepika Mathur
Satya Prakash
Gajendra P. S. Raghava
ResearchOpen Access07 Nov 2016
Scientific Reports

Volume: 6, P: 1-7
The regulatory landscape for actively personalized cancer immunotherapies

Cedrik M Britten
Harpreet Singh-Jasuja
Ulrich Kalinke
Correspondence08 Oct 2013
Nature Biotechnology

Volume: 31, P: 880-882
Repurposing FDA approved drugs for psoriasis indications through integrated molecular docking, one-SVM algorithm, and molecular dynamics simulation approaches

Saumya Choudhary
Noor Saba Khan
Neeraj Kumar
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-16
Characterization and regulation of salt upregulated cyclophilin from a halotolerant strain of Penicillium oxalicum

Mangaljeet Singh
Harpreet Singh
Prabhjeet Singh
ResearchOpen Access13 Oct 2023
Scientific Reports

Volume: 13, P: 1-15
MIDAS: a new platform for quality-graded health data for AI-enabled healthcare in India

Dibyajyoti Maity
Rohit Satish
Debnath Pal
Correspondence29 Aug 2024
Nature Medicine

Volume: 30, P: 2704-2705
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Openshaw and colleagues find myeloid inflammation and complement activation signatures in patients with long COVID who were previously hospitalized.

Felicity Liew
Claudia Efstathiou
J. Eunice Zhang
ResearchOpen Access08 Apr 2024
Nature Immunology

Volume: 25, P: 607-621
Designing a bed-side system for predicting length of stay in a neonatal intensive care unit

Harpreet Singh
Su Jin Cho
Yao Sun
ResearchOpen Access08 Feb 2021
Scientific Reports

Volume: 11, P: 1-13
RNA editing derived epitopes function as cancer antigens to elicit immune responses

RNA editing is a biological process that creates sequence variation. Here the authors show that peptides generated as a consequence of RNA editing are naturally presented by human leukocyte antigen (HLA) and serve as antigens to elicit anti-tumour immune responses.

Minying Zhang
Jens Fritsche
Patrick Hwu
ResearchOpen Access25 Sept 2018
Nature Communications

Volume: 9, P: 1-10
Publisher Correction: Actively personalized vaccination trial for newly diagnosed glioblastoma

Norbert Hilf
Sabrina Kuttruff-Coqui
Wolfgang Wick
Amendments and Corrections07 Feb 2019
Nature

Volume: 566, P: E13
Chameleon swarm algorithm with Morlet wavelet mutation for superior optimization performance

Vipan Kusla
Gurbinder Singh Brar
Walid El-Shafai
ResearchOpen Access22 Apr 2025
Scientific Reports

Volume: 15, P: 1-35
Insight mechanism of magnetic activated catalyst derived from recycled steel residue for black liquor degradation

Zacek David Flores-López
Aylín Belén Solís-Díaz
Nabisab Mujawar Mubarak
ResearchOpen Access17 Aug 2024
Scientific Reports

Volume: 14, P: 1-13
Grand challenges in bioinformatics education and training

With the increasing need for bioinformatics expertise in the life sciences, a coordinated effort is needed to proactively and critically reflect on the challenges of educating and training life scientists with the necessary skills and competencies.

Esra Büşra Işık
Michelle D. Brazas
Asif M. Khan
Comments & Opinion11 Aug 2023
Nature Biotechnology

Volume: 41, P: 1171-1174
Accelerated approvals hit the target in precision oncology

Vivek Subbiah
Lori J. Wirth
Gautam U. Mehta
Correspondence03 Oct 2022
Nature Medicine

Volume: 28, P: 1976-1979
Deep learning to quantify care manipulation activities in neonatal intensive care units

Abrar Majeedi
Ryan M. McAdams
Yin Li
ResearchOpen Access27 Jun 2024
npj Digital Medicine

Volume: 7, P: 1-9
Tracing the COVID-19 spread pattern in India through a GIS-based spatio-temporal analysis of interconnected clusters

Mousumi Gupta
Arpan Sharma
Amlan Gupta
ResearchOpen Access08 Jan 2024
Scientific Reports

Volume: 14, P: 1-13
Modulation of atrazine-induced chromosomal aberrations and cyclin-dependent kinases by aqueous extract of Roylea cinerea (D.Don) Baillon leaves in Allium cepa

Farhana Rashid
Davinder Singh
Saroj Arora
ResearchOpen Access22 Jul 2022
Scientific Reports

Volume: 12, P: 1-13
An augmentation aided concise CNN based architecture for COVID-19 diagnosis in real time

Balraj Preet Kaur
Harpreet Singh
Mohd Asif Shah
ResearchOpen Access11 Jan 2024
Scientific Reports

Volume: 14, P: 1-31
Inhibition of BK_Ca channels protects neonatal hearts against myocardial ischemia and reperfusion injury

Shridhar Sanghvi
Kalina Szteyn
Harpreet Singh
ResearchOpen Access07 Apr 2022
Cell Death Discovery

Volume: 8, P: 1-13
Actively personalized vaccination trial for newly diagnosed glioblastoma

In a phase I trial, highly individualized peptide vaccines against unmutated tumour antigens and neoepitopes elicited sustained responses in CD8⁺ and CD4⁺ T cells, respectively, in patients with newly diagnosed glioblastoma.

Norbert Hilf
Sabrina Kuttruff-Coqui
Wolfgang Wick
Research19 Dec 2018
Nature

Volume: 565, P: 240-245
A Novel Relative Permeability Model for Gas and Water Flow in Hydrate-Bearing Sediments With Laboratory and Field-Scale Application

Harpreet Singh
Evgeniy M. Myshakin
Yongkoo Seol
ResearchOpen Access30 Mar 2020
Scientific Reports

Volume: 10, P: 1-17
Single channel properties of mitochondrial large conductance potassium channel formed by BK-VEDEC splice variant

Shur Gałecka
Bogusz Kulawiak
Adam Szewczyk
ResearchOpen Access25 May 2021
Scientific Reports

Volume: 11, P: 1-12
Genome-wide characterization of peptidyl-prolyl cis–trans isomerases in Penicillium and their regulation by salt stress in a halotolerant P. oxalicum

Mangaljeet Singh
Kirandeep Kaur
Prabhjeet Singh
ResearchOpen Access10 Jun 2021
Scientific Reports

Volume: 11, P: 1-19
Convergent evolution of a genomic rearrangement may explain cancer resistance in hystrico- and sciuromorpha rodents

Yachna Jain
Keerthivasan Raanin Chandradoss
Kuljeet Singh Sandhu
ResearchOpen Access01 Sept 2021
npj Aging and Mechanisms of Disease

Volume: 7, P: 1-15
Challenges and recommendations for enhancing digital data protection in Indian Medical Research and Healthcare Sector

Anubhuti Sood
Deepika Mishra
Venkateswaran K. Iyer
ReviewsOpen Access22 Jan 2025
npj Digital Medicine

Volume: 8, P: 1-5
CTAB-crafted ZnO nanostructures for environmental remediation and pathogen control

Jyoti Gaur
Sanjeev Kumar
Omar El Outassi
ResearchOpen Access04 Sept 2024
Scientific Reports

Volume: 14, P: 1-22
Burden of gout among different WHO regions, 1990–2019: estimates from the global burden of disease study

Shoheera Punjwani
Chinmay Jani
Shiv T. Sehra
ResearchOpen Access10 Jul 2024
Scientific Reports

Volume: 14, P: 1-12
Cystic fibrosis-related mortality in the United States from 1999 to 2020: an observational analysis of time trends and disparities

Harpreet Singh
Chinmay Jani
Justin D. Salciccioli
ResearchOpen Access12 Sept 2023
Scientific Reports

Volume: 13, P: 1-12
Synergy of Physico-chemical and Biological Experiments for Developing a Cyclooxygenase-2 Inhibitor

Palwinder Singh
Jagroop Kaur
Rajbir Bhatti
ResearchOpen Access03 Jul 2018
Scientific Reports

Volume: 8, P: 1-14
Trends in prostate cancer mortality in the United States of America, by state and race, from 1999 to 2019: estimates from the centers for disease control WONDER database

Chinmay Jani
Christian Mouchati
Rana R. McKay
Research16 Dec 2022
Prostate Cancer and Prostatic Diseases

Volume: 26, P: 552-562

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