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Neutralizing and binding antibodies are a correlate of risk of COVID-19 in the CoVPN 3008 study in people with HIV

Using data from the CoVPN 3008 study, the authors show that the neutralizing antibody correlate of risk holds in people living with HIV. However, the nAb correlate was weaker and shorter-lived in a vaccine-immunity versus hybrid-immunity population.

Nonhlanhla N. Mkhize
Bo Zhang
Peter B. Gilbert
ResearchOpen Access06 Oct 2025
Nature Communications

Volume: 16, P: 1-19
Oligomerisation of Ku from Mycobacterium tuberculosis promotes DNA synapsis

Mycobacterium tuberculosis protein Ku is involved in DNA repair and a potential drug target. Here, using cryo-EM and complementary approaches, the authors obtain insights into Ku oligomerization and mechanisms of function in DNA synapsis.

Sayma Zahid
Sonia Baconnais
Amanda K. Chaplin
ResearchOpen Access26 Nov 2025
Nature Communications

Volume: 16, P: 1-13
Experimental Cancer Medicine Centre (ECMC) network proposal for a consensus gene panel for pan-cancer sequencing: a Delphi methodology

Richard Phillips
Bristi Basu
Andrew D. Beggs
ResearchOpen Access08 Nov 2025
British Journal of Cancer

Volume: 134, P: 289-294
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Homologous recombination promotes non-immunogenic mitotic cell death upon DNA damage

Szmyd et al. show that DNA repair pathways impact whether cells with DNA lesions arrest in mitosis. The formation of homologous recombination-driven double Holliday junctions elicits mitotic cell death and suppresses inflammatory signalling.

Radoslaw Szmyd
Sienna Casolin
Anthony J. Cesare
ResearchOpen Access13 Jan 2025
Nature Cell Biology

Volume: 27, P: 59-72
Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution

Circulating tumour DNA profiling in early-stage non-small-cell lung cancer can be used to track single-nucleotide variants in plasma to predict lung cancer relapse and identify tumour subclones involved in the metastatic process.

Christopher Abbosh
Nicolai J. Birkbak
Charles Swanton
Research26 Apr 2017
Nature

Volume: 545, P: 446-451
Africa-specific human genetic variation near CHD1L associates with HIV-1 load

Africa-specific genetic variation on chromosome 1 near CHD1L is associated with HIV replication in vivo.

Paul J. McLaren
Immacolata Porreca
Jacques Fellay
Research02 Aug 2023
Nature

Volume: 620, P: 1025-1030
Effects of Birth-Related Events on Blood Flow Distribution

Harriet S Iwamoto
David Teitel
Abraham M Rudolph
Research01 Dec 1987
Pediatric Research

Volume: 22, P: 634-640
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
A gut microbiota rheostat forecasts responsiveness to PD-L1 and VEGF blockade in mesothelioma

Although immune checkpoint blockade is a standard treatment for patients with malignant mesothelioma, only a minority of patients exhibit radiological response. In a phase II clinical trial (MIST4) investigating the efficacy, safety and molecular correlates of response following treatment with atezolizumab and bevacizumab, the authors demonstrate that the gut microbiota may modulate responsiveness to treatment.

Min Zhang
Aleksandra Bzura
Dean A. Fennell
ResearchOpen Access21 Aug 2024
Nature Communications

Volume: 15, P: 1-14
Nobel panel rewards prion theory after years of heated debate

london
The 1997 Nobel Prize in Physiology and Medicine was awarded this week to Stanley Prusiner of the University of California, San Francisco, for his contributions towards the identification of the infectious agent that causes diseases such as BSE in cows, scrapie in sheep and Creutzfeldt-Jakob disease in humans.

Harriet Coles
News09 Oct 1997
Nature

Volume: 389, P: 529
Author Correction: Africa-specific human genetic variation near CHD1L associates with HIV-1 load

Paul J. McLaren
Immacolata Porreca
Jacques Fellay
Amendments and Corrections05 Sept 2023
Nature

Volume: 621, P: E42
HYPERCHLOREMIA AND HYPERNATREMIA ASSOCIATED WITH CHOLESTYRAMINE THERAPY

William A Primack
Lawrence M Gartner
Adrian Spitzer
Research01 Apr 1977
Pediatric Research

Volume: 11, P: 520
Risk-stratified treatment for drug-susceptible pulmonary tuberculosis

Authors perform an analysis of the patient data and risk factors to evaluate unfavorable outcomes and adverse events in adults with pulmonary tuberculosis treated with a 4-month rifapentine based regimen. Low rifapentine exposure was the most clinically significant risk factor for treatment failure and tuberculosis relapse.

Vincent K. Chang
Marjorie Z. Imperial
Elizabeth Guy
ResearchOpen Access30 Oct 2024
Nature Communications

Volume: 15, P: 1-12
Neoantigen-directed immune escape in lung cancer evolution

RNA sequencing data and tumour pathology observations of non-small-cell lung cancers indicate that the immune cell microenvironment exerts strong evolutionary selection pressures that shape the immune-evasion capacity of tumours.

Rachel Rosenthal
Elizabeth Larose Cadieux
Andrew Kidd
Research20 Mar 2019
Nature

Volume: 567, P: 479-485
Effects of Birth-Related Events on Central Blood Flow Patterns

David F Teitel
Harriet S Iwamoto
Abraham M Rudolph
Research01 Nov 1987
Pediatric Research

Volume: 22, P: 557-566
Effect of Birth-Related Events on Metabolism in Fetal Sheep

Harriet S Iwamoto
David F Teitel
Abraham M Rudolph
Research01 Aug 1991
Pediatric Research

Volume: 30, P: 158-164
Whole-genome sequencing of patients with rare diseases in a national health system

Whole-genome sequencing and phenotype data sharing are introduced in a national health system to streamline diagnosis and to discover coding and non-coding variants that cause rare diseases.

Ernest Turro
William J. Astle
Willem H. Ouwehand
Research24 Jun 2020
Nature

Volume: 583, P: 96-102
Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
Amendments and CorrectionsOpen Access11 Jul 2023
Nature

Volume: 619, P: E61
Author Correction: Risk-stratified treatment for drug-susceptible pulmonary tuberculosis

Vincent K. Chang
Marjorie Z. Imperial
Elizabeth Guy
Amendments and CorrectionsOpen Access13 May 2025
Nature Communications

Volume: 16, P: 1
Sympathoadrenal, Metabolic, and Regional Blood Flow Responses to Cold in Fetal Sheep

Frank Van Bel
Christine Roman
Abraham M Rudolph
Research01 Jul 1993
Pediatric Research

Volume: 34, P: 47-50
Role of gene signatures combined with pathology in classification of oropharynx head and neck cancer

Andrew Dhawan
Jacob Scott
Harriet E. Gee
ResearchOpen Access23 Jun 2020
Scientific Reports

Volume: 10, P: 1-10
A clinically driven variant prioritization framework outperforms purely computational approaches for the diagnostic analysis of singleton WES data

Zornitza Stark
Harriet Dashnow
Paul A James
Research23 Aug 2017
European Journal of Human Genetics

Volume: 25, P: 1268-1272
Prevalence and seasonal variation of tick-borne haemoparasites in cattle from north-eastern Uganda

Patrick Etiang
Maureen Kamusiime
Dennis Muhanguzi
ResearchOpen Access19 Aug 2025
Scientific Reports

Volume: 15, P: 1-19
A call for action: closing the gap on ethnic disparities in oral cavity cancer care

Nikila Patil
Zainab Lal
Harriet S. Walter
Comments & OpinionOpen Access10 Sept 2025
British Journal of Cancer

Volume: 133, P: 917-918
Phase 1b study of tirabrutinib in combination with idelalisib or entospletinib in previously treated B-cell lymphoma

Franck Morschhauser
Martin J. S. Dyer
Gilles Salles
ResearchOpen Access17 Dec 2020
Leukemia

Volume: 35, P: 2108-2113
A novel Alzheimer disease locus located near the gene encoding tau protein

G Jun
C A Ibrahim-Verbaas
L A Farrer
Research17 Mar 2015
Molecular Psychiatry

Volume: 21, P: 108-117

Search

Neutralizing and binding antibodies are a correlate of risk of COVID-19 in the CoVPN 3008 study in people with HIV

Oligomerisation of Ku from Mycobacterium tuberculosis promotes DNA synapsis

Experimental Cancer Medicine Centre (ECMC) network proposal for a consensus gene panel for pan-cancer sequencing: a Delphi methodology

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Mapping the human genetic architecture of COVID-19

Homologous recombination promotes non-immunogenic mitotic cell death upon DNA damage

Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution

Africa-specific human genetic variation near CHD1L associates with HIV-1 load

Effects of Birth-Related Events on Blood Flow Distribution

A second update on mapping the human genetic architecture of COVID-19

A gut microbiota rheostat forecasts responsiveness to PD-L1 and VEGF blockade in mesothelioma

Nobel panel rewards prion theory after years of heated debate

Author Correction: Africa-specific human genetic variation near CHD1L associates with HIV-1 load

HYPERCHLOREMIA AND HYPERNATREMIA ASSOCIATED WITH CHOLESTYRAMINE THERAPY

Risk-stratified treatment for drug-susceptible pulmonary tuberculosis

Neoantigen-directed immune escape in lung cancer evolution

Effects of Birth-Related Events on Central Blood Flow Patterns

Effect of Birth-Related Events on Metabolism in Fetal Sheep

Whole-genome sequencing of patients with rare diseases in a national health system

Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Author Correction: Risk-stratified treatment for drug-susceptible pulmonary tuberculosis

Sympathoadrenal, Metabolic, and Regional Blood Flow Responses to Cold in Fetal Sheep

Role of gene signatures combined with pathology in classification of oropharynx head and neck cancer

A clinically driven variant prioritization framework outperforms purely computational approaches for the diagnostic analysis of singleton WES data

Prevalence and seasonal variation of tick-borne haemoparasites in cattle from north-eastern Uganda

A call for action: closing the gap on ethnic disparities in oral cavity cancer care

Phase 1b study of tirabrutinib in combination with idelalisib or entospletinib in previously treated B-cell lymphoma

A novel Alzheimer disease locus located near the gene encoding tau protein

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