Nature Search

Structural and immunological similarities between simian sarcoma virus gene product(s) and human platelet-derived growth factor

Keith C. Robbins
Harry N. Antoniades
Stuart A. Aaronson
Research13 Oct 1983
Nature

Volume: 305, P: 605-608
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
The role of the gut microbiota in nutrition and health

The human gut harbours a vast array of micro-organisms and the benefits of these bacteria should not be forgotten. Here, Flint and colleagues discuss the role of the gut microbiota in nutrition and health, describing the development of these bacteria in the healthy gut, and their positive influences on microbial and human metabolism.

Harry J. Flint
Karen P. Scott
Sylvia H. Duncan
Reviews04 Sept 2012
Nature Reviews Gastroenterology & Hepatology

Volume: 9, P: 577-589
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Polysaccharide utilization by gut bacteria: potential for new insights from genomic analysis

Dietary plant polysaccharides are a major energy source for the anaerobic microbiota that inhabit the mammalian large intestine and rumen. Flint and colleagues discuss polysaccharide utilization by gut anaerobes, focusing on two examples, the use of insoluble structural polysaccharides byRuminococcus flavefaciens and the use of starch by Bacteroides thetaiotaomicron.

Harry J. Flint
Edward A. Bayer
Bryan A. White
Reviews01 Feb 2008
Nature Reviews Microbiology

Volume: 6, P: 121-131
Antibiotics and adiposity

Mice receiving low doses of certain antibiotics gain weight and accumulate fat. This could be because some gut bacteria survive the treatment better than others, shifting digestion towards greater energy provision. See Article p.621

Harry J. Flint
News & Views29 Aug 2012
Nature

Volume: 488, P: 601-602
The gut anaerobe Faecalibacterium prausnitzii uses an extracellular electron shuttle to grow at oxic–anoxic interphases

M Tanweer Khan
Sylvia H Duncan
Hermie J M Harmsen
Research23 Feb 2012
The ISME Journal

Volume: 6, P: 1578-1585
Mechanistic insights into consumption of the food additive xanthan gum by the human gut microbiota

The human gut microbiota can metabolize xanthan gum, a food additive that was introduced to our diets relatively recently in processed foods. A Ruminococcaceae species can degrade this complex polysaccharide and, in some individuals, Bacteroides intestinalis can grow on the released oligosaccharide products.

Matthew P. Ostrowski
Sabina Leanti La Rosa
Eric C. Martens
Research01 Apr 2022
Nature Microbiology

Volume: 7, P: 556-569
The gut microbiota, bacterial metabolites and colorectal cancer

Accumulating evidence suggests that the gut microbiota has a role in the aetiology of colorectal cancer (CRC). In this Review, Flint and colleagues discuss the complex interplay between diet, the microbiota and microbial metabolites and argue that the combined metabolome of the microbiota has both protective and detrimental effects on inflammation and the progression of CRC.

Petra Louis
Georgina L. Hold
Harry J. Flint
Reviews08 Sept 2014
Nature Reviews Microbiology

Volume: 12, P: 661-672
Structural dissection and high-throughput screening of mannosylglycerate synthase

James Flint
Edward Taylor
Gideon J Davies
Research12 Jun 2005
Nature Structural & Molecular Biology

Volume: 12, P: 608-614
Specific substrate-driven changes in human faecal microbiota composition contrast with functional redundancy in short-chain fatty acid production

Nicole Reichardt
Maren Vollmer
Petra Louis
Research01 Dec 2017
The ISME Journal

Volume: 12, P: 610-622
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Phylogenetic distribution of three pathways for propionate production within the human gut microbiota

Nicole Reichardt
Sylvia H Duncan
Petra Louis
Research20 Feb 2014
The ISME Journal

Volume: 8, P: 1323-1335
Impact of diet and individual variation on intestinal microbiota composition and fermentation products in obese men

Anne Salonen
Leo Lahti
Willem M de Vos
Research24 Apr 2014
The ISME Journal

Volume: 8, P: 2218-2230
Effect of carbohydrate digestibility on appetite and its relationship to postprandial blood glucose and insulin levels

H P F Peters
P Ravestein
D J Mela
Research15 Sept 2010
European Journal of Clinical Nutrition

Volume: 65, P: 47-54
The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic

Probiotics are widely regarded as live microorganisms that, when administered in sufficient amounts, confer a health benefit, but guidance is needed on the most appropriate use of the term. This Consensus Statement outlines recommendations for the scope and definition of the term 'probiotic' as determined by an expert panel convened by the International Scientific Association for Probiotics and Prebiotics in October 2013.

Colin Hill
Francisco Guarner
Mary Ellen Sanders
ReviewsOpen Access10 Jun 2014
Nature Reviews Gastroenterology & Hepatology

Volume: 11, P: 506-514
Ruminococcus bromii is a keystone species for the degradation of resistant starch in the human colon

Xiaolei Ze
Sylvia H Duncan
Harry J Flint
Research16 Feb 2012
The ISME Journal

Volume: 6, P: 1535-1543
Telomerase activity during spontaneous immortalization of Li-Fraumeni syndrome skin fibroblasts

Lauren S Gollahon
Eliyahu Kraus
Michael A Tainsky
Research14 Aug 1998
Oncogene

Volume: 17, P: 709-717
Cultivation and sequencing of rumen microbiome members from the Hungate1000 Collection

Rumen microbiome biology gets a boost with the release of 410 high-quality reference genomes from the Hungate1000 project.

Rekha Seshadri
Sinead C Leahy
William J Kelly
ResearchOpen Access19 Mar 2018
Nature Biotechnology

Volume: 36, P: 359-367
Congenital generalized lipodystrophies—new insights into metabolic dysfunction

Patients with congenital generalized lipodystrophy (CGL) have a near total absence of body fat owing to mutations in genes involved in lipid storage. This Review describes the genetic pathophysiology of the four main forms of CGL and makes recommendations for their appropriate diagnosis and management. Specific therapies for CGL are currently limited, but the authors highlight novel drugs currently in development to treat this condition.

Nivedita Patni
Abhimanyu Garg
Reviews04 Aug 2015
Nature Reviews Endocrinology

Volume: 11, P: 522-534
Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
Amendments and CorrectionsOpen Access11 Jul 2023
Nature

Volume: 619, P: E61
Dominant and diet-responsive groups of bacteria within the human colonic microbiota

Alan W Walker
Jennifer Ince
Harry J Flint
Research05 Aug 2010
The ISME Journal

Volume: 5, P: 220-230
Towards standards for human fecal sample processing in metagenomic studies

Testing 21 different fecal DNA extraction protocols in multiple laboratories results in a standardized protocol with the potential to improve comparability across human gut microbiome studies.

Paul I Costea
Georg Zeller
Peer Bork
Research02 Oct 2017
Nature Biotechnology

Volume: 35, P: 1069-1076
Ecoregional and temporal dynamics of dugong habitat use in a complex coral reef lagoon ecosystem

Solène Derville
Christophe Cleguer
Claire Garrigue
ResearchOpen Access11 Jan 2022
Scientific Reports

Volume: 12, P: 1-15
Faecalibacterium prausnitzii A2-165 has a high capacity to induce IL-10 in human and murine dendritic cells and modulates T cell responses

Oriana Rossi
Lisette A. van Berkel
Jerry M. Wells
ResearchOpen Access04 Jan 2016
Scientific Reports

Volume: 6, P: 1-12
Complexity of the Ruminococcus flavefaciens FD-1 cellulosome reflects an expansion of family-related protein-protein interactions

Vered Israeli-Ruimy
Pedro Bule
Edward A. Bayer
ResearchOpen Access10 Feb 2017
Scientific Reports

Volume: 7, P: 1-15
Dietary fibers inhibit obesity in mice, but host responses in the cecum and liver appear unrelated to fiber-specific changes in cecal bacterial taxonomic composition

Janice E. Drew
Nicole Reichardt
Petra Louis
ResearchOpen Access22 Oct 2018
Scientific Reports

Volume: 8, P: 1-11
Erratum: Phylogenetic distribution of three pathways for propionate production within the human gut microbiota

Nicole Reichardt
Sylvia H Duncan
Petra Louis
Amendments and Corrections20 May 2014
The ISME Journal

Volume: 8, P: 1352
The effect of protease inhibitors derived from potato formulated in a minidrink on appetite, food intake and plasma cholecystokinin levels in humans

H P F Peters
M Foltz
S A Wiseman
Research20 Jul 2010
International Journal of Obesity

Volume: 35, P: 244-250
Oral treatment with Eubacterium hallii improves insulin sensitivity in db/db mice

Shanthadevi Udayappan
Louise Manneras-Holm
Max Nieuwdorp
ResearchOpen Access06 Jul 2016
npj Biofilms and Microbiomes

Volume: 2, P: 1-10
Challenges in microbial ecology: building predictive understanding of community function and dynamics

Stefanie Widder
Rosalind J Allen
Orkun S Soyer
ReviewsOpen Access29 Mar 2016
The ISME Journal

Volume: 10, P: 2557-2568
The effect of a low-energy food foam on appetite measures during a 1-day reduced-energy meal plan

H P F Peters
W P Koppenol
D J Mela
Research01 Aug 2014
International Journal of Obesity

Volume: 39, P: 361-367
Hair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes

Liz Rietschel
Fabian Streit
Marcella Rietschel
ResearchOpen Access10 Nov 2017
Scientific Reports

Volume: 7, P: 1-15

Search

Structural and immunological similarities between simian sarcoma virus gene product(s) and human platelet-derived growth factor

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

The role of the gut microbiota in nutrition and health

Mapping the human genetic architecture of COVID-19

Polysaccharide utilization by gut bacteria: potential for new insights from genomic analysis

Antibiotics and adiposity

The gut anaerobe Faecalibacterium prausnitzii uses an extracellular electron shuttle to grow at oxic–anoxic interphases

Mechanistic insights into consumption of the food additive xanthan gum by the human gut microbiota

The gut microbiota, bacterial metabolites and colorectal cancer

Structural dissection and high-throughput screening of mannosylglycerate synthase

Specific substrate-driven changes in human faecal microbiota composition contrast with functional redundancy in short-chain fatty acid production

A second update on mapping the human genetic architecture of COVID-19

Phylogenetic distribution of three pathways for propionate production within the human gut microbiota

Impact of diet and individual variation on intestinal microbiota composition and fermentation products in obese men

Effect of carbohydrate digestibility on appetite and its relationship to postprandial blood glucose and insulin levels

The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic

Ruminococcus bromii is a keystone species for the degradation of resistant starch in the human colon

Telomerase activity during spontaneous immortalization of Li-Fraumeni syndrome skin fibroblasts

Cultivation and sequencing of rumen microbiome members from the Hungate1000 Collection

Congenital generalized lipodystrophies—new insights into metabolic dysfunction

Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Dominant and diet-responsive groups of bacteria within the human colonic microbiota

Towards standards for human fecal sample processing in metagenomic studies

Ecoregional and temporal dynamics of dugong habitat use in a complex coral reef lagoon ecosystem

Faecalibacterium prausnitzii A2-165 has a high capacity to induce IL-10 in human and murine dendritic cells and modulates T cell responses

Complexity of the Ruminococcus flavefaciens FD-1 cellulosome reflects an expansion of family-related protein-protein interactions

Dietary fibers inhibit obesity in mice, but host responses in the cecum and liver appear unrelated to fiber-specific changes in cecal bacterial taxonomic composition

Erratum: Phylogenetic distribution of three pathways for propionate production within the human gut microbiota

The effect of protease inhibitors derived from potato formulated in a minidrink on appetite, food intake and plasma cholecystokinin levels in humans

Oral treatment with Eubacterium hallii improves insulin sensitivity in db/db mice

Challenges in microbial ecology: building predictive understanding of community function and dynamics

The effect of a low-energy food foam on appetite measures during a 1-day reduced-energy meal plan

Hair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes

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