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Showing 1–4 of 4 results
Advanced filters: Author: Harshwardhan Poddar Clear advanced filters

  • Photoreceptor proteins utilise biological chromophores to regulate a large range of cellular processes in response to light. Here the authors identify and characterise a sub-family of multi-centre photoreceptors, termed photocobilins, that not only utilise B12 but also contain biliverdin (BV) as an additional chromophore.

    • Shaowei Zhang
    • Laura N. Jeffreys
    • Nigel S. Scrutton
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • CarH is a bacterial B12-binding photoreceptor involved in transcriptional regulation. Here, the authors provide insights into B12 dynamics and associated cobalt redox changes following light activation. These demonstrate the CarH response integrates light and oxygen sensing.

    • Harshwardhan Poddar
    • Ronald Rios-Santacruz
    • David Leys
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • The Michael-type addition reaction is used for carbon-carbon bond formation; however biocatalytic methods for this reaction are rare. Here, the authors generate and exploit mutability landscapes of 4-oxalocrotonate tautomerase to direct the redesign of this promiscuous enzyme into enantio-complementary Michaelases.

    • Jan-Ytzen van der Meer
    • Harshwardhan Poddar
    • Gerrit J. Poelarends
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-16