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Showing 1–7 of 7 results
Advanced filters: Author: Hasan Yardimci Clear advanced filters

  • The authors determined high-resolution cryo-EM structures of the lentiviral intasome — the nucleoprotein complex that inserts viral DNA into a host chromosome — and show that the architecture comprising 16 integrase subunits is critical for its function.

    • Allison Ballandras-Colas
    • Vidya Chivukula
    • Peter Cherepanov
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • During eukaryotic chromosome replication cells utilize ring-shaped CMG helicase that separates the two strands of the DNA double helix. Here the authors reveal that CMG helicase activity is inhibited by duplex DNA engagement at the fork, which is relieved by binding of RPA to the lagging-strand template.

    • Hazal B. Kose
    • Sherry Xie
    • Hasan Yardimci
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15

  • How the eukaryotic helicase unzips DNA during replication is not well understood. By measuring the real-time motion of purified CMG unwinding DNA with magnetic tweezers, the authors reveal the dynamics where isolated CMG unwinds via a biased random walk with proclivity to pause.

    • Daniel R. Burnham
    • Hazal B. Kose
    • Hasan Yardimci
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • Here, the authors show that a DnaA:origin complex promotes specific nucleobase capture from a single DNA strand. It is proposed that this mechanism may play a key role stimulating opening of bacterial chromosome origins.

    • Simone Pelliciari
    • Salomé Bodet-Lefèvre
    • Heath Murray
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • Single-molecule and ensemble assays are used to show that large T antigen, the replicative DNA helicase of the simian virus 40 (SV40), unwinds DNA as a single hexamer by steric exclusion and is able to bypass covalent DNA–protein crosslinks.

    • Hasan Yardimci
    • Xindan Wang
    • Johannes C. Walter
    Research
    Nature
    Volume: 492, P: 205-209

  • DNA replication begins with prereplication-complex formation at origins and is followed by helicase activation to unwind DNA at the replication fork. This Perspective compares bacterial DnaB and eukaryotic MCM2–7 helicase-loading mechanisms and discusses emerging data supporting current models of how two MCM2–7 complexes are loaded to form a double hexamer.

    • Hasan Yardimci
    • Johannes C Walter
    Reviews
    Nature Structural & Molecular Biology
    Volume: 21, P: 20-25