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Showing 1–3 of 3 results
Advanced filters: Author: Hasane Ratni Clear advanced filters

  • Reengineering polyketide synthase encoding genes to produce analogues of natural products can be slow and low-yielding. Here the authors use accelerated evolution to recombine the gene cluster for rapid production of rapamycin-related products.

    • Aleksandra Wlodek
    • Steve G. Kendrew
    • Matthew A. Gregory
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-10

  • NMR-based structural analysis of the RNA duplex formed by SMN2 exon 7 and U1 snRNA reveals that the splicing modifier SMN-C5 pulls the bulged adenine into the RNA helix base stack and transforms the weak 5ʹ splice site of SMN2 exon 7 into a stronger one.

    • Sébastien Campagne
    • Sarah Boigner
    • Frédéric H.-T. Allain
    Research
    Nature Chemical Biology
    Volume: 15, P: 1191-1198

  • Small molecules correcting the splicing deficit of the survival of motor neuron 2 (SMN2) gene have been identified as having therapeutic potential. Here, the authors provide evidence that SMN2 mRNA forms a ribonucleoprotein complex that can be specifically targeted by these small molecules.

    • Manaswini Sivaramakrishnan
    • Kathleen D. McCarthy
    • Friedrich Metzger
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-13