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Showing 1–3 of 3 results
Advanced filters: Author: Hassane El Mkami Clear advanced filters

  • How mechanosensitive ion channels, such as MscL, are activated by lipids and physical properties of the membrane remains unclear. Here authors use PELDOR/DEER spectroscopy and identify a single site which generated an allosteric structural response in the absence of membrane tension.

    • Charalampos Kapsalis
    • Bolin Wang
    • Christos Pliotas
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • Histone chaperone RbAp48 interacts with histones H3–H4 and delivers them to a second histone chaperone, ASF1, to be assembled into new nucleosomes. These interactions are now investigated, revealing that RbAp48 binds H3–H4 heterodimers (but not tetramers) and causes conformational changes in their core fold. Moreover, an allosteric mechanism facilitates exchange of H3–H4 between RbAp48 and ASF1.

    • Wei Zhang
    • Marek Tyl
    • Ernest D Laue
    Research
    Nature Structural & Molecular Biology
    Volume: 20, P: 29-35

  • Dynamic nuclear polarization is a technique to enhance NMR signals, often achieved by continuous-wave irradiation of the samples. Here, the authors create large polarization gradients by using high-power chirped inversion pulses at 94 GHz at an average power of a few hundred mW with fast build-up times, reaching NMR signal enhancements of up to 340.

    • Yujie Zhao
    • Hassane El Mkami
    • Graham M. Smith
    ResearchOpen Access
    Communications Chemistry
    Volume: 6, P: 1-12