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Showing 1–10 of 10 results
Advanced filters: Author: Hayley J Sharpe Clear advanced filters

  • Sergey Nikolaev, Stylianos Antonarakis and colleagues analyze the genetic architecture of 293 basal cell carcinomas (BCCs) and characterize their mutational landscape. They observe UV signature mutations and identify new driver mutations in MYCN, PTPN14 and LATS1 in BCC.

    • Ximena Bonilla
    • Laurent Parmentier
    • Sergey I Nikolaev
    Research
    Nature Genetics
    Volume: 48, P: 398-406

  • Receptor-linked protein tyrosine phosphatases (RPTPs) usually contain an active membrane proximal domain and an inactive pseudophosphatase domain. Here, the authors characterize an RPTP with two pseudophosphatase domains, providing evidence that it may act as a decoy receptor for substrate sequestration.

    • Iain M. Hay
    • Gareth W. Fearnley
    • Janet E. Deane
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13

  • Epidemiological analyses coupled with immunological phenotyping suggest that humoral immunity induced by COVID-19 vaccines wanes more rapidly in individuals with severe obesity compared to individuals with a BMI within the normal range.

    • Agatha A. van der Klaauw
    • Emily C. Horner
    • James E. D. Thaventhiran
    ResearchOpen Access
    Nature Medicine
    Volume: 29, P: 1146-1154

  • 20(S)-hydroxycholesterol, a naturally occurring oxysterol, activates the Hedgehog signaling pathway by directly binding an allosteric site on Smoothened.

    • Hayley J Sharpe
    • Frederic J de Sauvage
    News & Views
    Nature Chemical Biology
    Volume: 8, P: 139-140

  • Insufficient AHR activation has been suggested in SLE, and augmenting AHR activation therapeutically may prevent CXCL13+ TPH/TFH differentiation and the subsequent recruitment of B cells and formation of lymphoid aggregates in inflamed tissues.

    • Calvin Law
    • Vanessa Sue Wacleche
    • Deepak A. Rao
    Research
    Nature
    Volume: 631, P: 857-866

  • Whipworms are large parasites causing chronic disease in humans and other mammals. Here, the authors show how larvae create tunnels inside the gut lining and reveal the early host response to infection via Isg15 in mice and murine caecaloids.

    • María A. Duque-Correa
    • David Goulding
    • Matthew Berriman
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • This Perspective discusses recent advances in understanding the structural and pharmacological properties of the downstream Hedgehog pathway effector Smoothened. Small molecule agonists and antagonists of Smo could be used as potential therapeutics.

    • Hayley J Sharpe
    • Weiru Wang
    • Frederic J de Sauvage
    Reviews
    Nature Chemical Biology
    Volume: 11, P: 246-255