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Showing 1–4 of 4 results
Advanced filters: Author: Hayley L. Rein Clear advanced filters

  • The tumor suppressor RAD51C is mutated in ovarian cancers. Through variant analysis the authors identify a mutation cluster in the RAD51C Walker B region important for the repair of DNA double-strand breaks and replicative damage. By identifying Walker B separation-of-function alleles, they show that these activities can be uncoupled.

    • Hayley L. Rein
    • Yashpal Rawal
    • Kara A. Bernstein
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13

  • The human Shu complex promotes homologous recombination by regulating RAD51. Here the authors reveal that the Shu complex proteins, SWSAP1-SWS1, decorate the RAD51 filament on ssDNA and facilitate its strand exchange reaction by stimulating RPA diffusion on ssDNA. Lastly, that SWSAP1-SWS1 knockouts are Olaparib sensitive.

    • Sarah R. Hengel
    • Katherine G. Oppenheimer
    • Kara A. Bernstein
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • Human SWS1, SWSAP1, and SPIDR interact with RAD51, a critical protein for homology-directed repair. Here the authors reveal roles for the mouse SWS1–SWSAP1–SPIDR complex in inter-homolog recombination, including during meiosis, and sister chromatid exchange in BLM helicase deficient cells.

    • Rohit Prakash
    • Thomas Sandoval
    • Maria Jasin
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15