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Showing 1–3 of 3 results
Advanced filters: Author: Hayley Strasburger Clear advanced filters

  • Microglia clearance activity in adult brain is regulated epigenetically and region-specifically to match neuronal attrition rates. Uncoupling this activity from neural apoptosis leads to aberrant microglia activation & neurodegenerative-like changes.

    • Pinar Ayata
    • Ana Badimon
    • Anne Schaefer
    Research
    Nature Neuroscience
    Volume: 21, P: 1049-1060

  • In multiple sclerosis (MS), antigen-presenting cells inducing cytotoxic T cell response against mature oligodendrocytes remain to be identified. Here the authors show that oligodendrocyte precursors cross-present antigen taken up from mature oligodendrocytes, and are targeted by cytotoxic T cells in cell culture and in an animal model of MS.

    • Leslie Kirby
    • Jing Jin
    • Peter A. Calabresi
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-20

  • Microglia, the brain’s immune cells, suppress neuronal activity in response to synaptic ATP release and alter behavioural responses in mice.

    • Ana Badimon
    • Hayley J. Strasburger
    • Anne Schaefer
    Research
    Nature
    Volume: 586, P: 417-423