Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–11 of 11 results
Advanced filters: Author: Hazem E. Ghoneim Clear advanced filters

  • The mechanism(s) controlling CD8+ virtual memory T cell (TVM) development are still under investigation. Here, using uninfected or IAV-challenged Ikzf3-deficient mice, the authors identify the transcription factor Aiolos as a negative regulator of TVM cell development by repressing Eomes and IL-15/STAT5 signaling.

    • Srijana Pokhrel
    • Gayathri Dileepan
    • Kenneth J. Oestreich
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-17

  • A proteotoxic stress response specific to exhausted T cells, governed by AKT signaling and accompanied by increased protein translation, represents a mechanistic vulnerability and a new therapeutic target to improve cancer immunotherapies.

    • Yi Wang
    • Anjun Ma
    • Zihai Li
    ResearchOpen Access
    Nature
    Volume: 647, P: 1025-1035

  • Cancer immunotherapies can be limited by terminally dysfunctional T cells in the tumor microenvironment. Here the authors present a model of stable human T cell dysfunction to show that TGFβ contributes to this terminal dysfunction which can be therapeutically inhibited by simultaneously blocking TGFβ1 and boosting bone morphogenetic protein (BMP) signaling.

    • Abbey A. Saadey
    • Amir Yousif
    • Hazem E. Ghoneim
    Research
    Nature Immunology
    Volume: 24, P: 280-294

  • Following clearance of chronic infections, virus-specific CD8+ T cells recover a subset of memory-related transcriptome features. Yet their unique open chromatin landscape largely reflects an exhausted or dysfunctional state, limiting their protective memory potential.

    • Amir Yousif
    • Hazem E. Ghoneim
    News & Views
    Nature Immunology
    Volume: 22, P: 938-940

  • Through iterative cycles of viral challenge and rechallenge over ten years, mouse T cells are demonstrated to have essentially infinite potential for population expansion and longevity without malignant transformation or loss of functional competence.

    • Andrew G. Soerens
    • Marco Künzli
    • David Masopust
    Research
    Nature
    Volume: 614, P: 762-766

  • Tissue-resident memory (TRM) cells are generally stably maintained in discrete tissues or organs. Masopust and colleagues show that TRM cells can reenter the circulation, and exhibit considerable plasticity, although they retain a proclivity to reestablish themselves in their tissue of origin.

    • Raissa Fonseca
    • Lalit K. Beura
    • David Masopust
    Research
    Nature Immunology
    Volume: 21, P: 412-421

  • Autoreactive T cells are subject to continuous antigenic stimulation yet sustain their autoreactive functionality. Youngblood and colleagues examine type 1 diabetes systems to show that a pool of autoreactive CD8+ T cells exhibits a stem cell–like signature that facilitates their durable activity.

    • Hossam A. Abdelsamed
    • Caitlin C. Zebley
    • Ben Youngblood
    Research
    Nature Immunology
    Volume: 21, P: 578-587

  • DNA methylation profiling of virus-specific T cells during acute viral infection in mice provides evidence that a fate-permissive subset of effector CD8 T cells dedifferentiates into long-lived memory T cells.

    • Ben Youngblood
    • J. Scott Hale
    • Rafi Ahmed
    Research
    Nature
    Volume: 552, P: 404-409