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Showing 1–2 of 2 results
Advanced filters: Author: Heather Doviak Clear advanced filters

  • Horitani, Chavkin et al. report that the loss of the Y chromosome in macrophages from failing human hearts correlates with cardiac fibroblast activation and that the deficiency of a single Y chromosome gene, Uty, triggers an epigenetic rewiring in macrophages toward a profibrotic phenotype and increases cardiac fibrosis and dysfunction that can be prevented by TGFβ-neutralizing antibodies.

    • Keita Horitani
    • Nicholas W. Chavkin
    • Kenneth Walsh
    Research
    Nature Cardiovascular Research
    Volume: 3, P: 343-355

  • Excessive activity of matrix metalloproteinases (MMPs) occurs in many diseases; however, the systemic administration of MMP inhibitors can cause undesirable, off-target effects and hence, clinical translation has been hampered. Now, injectable polysaccharide-based hydrogels are shown to enable the localized delivery of an inhibitor of MMP following the hydrogels’ degradation in response to MMP activity. This targeted approach shows efficacy in a myocardial infarction model in large animals.

    • Brendan P. Purcell
    • David Lobb
    • Jason A. Burdick
    Research
    Nature Materials
    Volume: 13, P: 653-661