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Retraction Note: NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages

Jong-Seok Moon
Kiichi Nakahira
Augustine M. K. Choi
Amendments and Corrections24 Nov 2023
Nature Medicine

Volume: 29, P: 3272
RETRACTED ARTICLE: NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages

In macrophages, Nox4 drives fatty acid metabolism, which in turn activates the NLRP3 inflammasome. This pathway can be pharmacologically targeted in vivo by inhibiting Nox4 to reduce S. pneumoniae infection in mice.

Jong-Seok Moon
Kiichi Nakahira
Augustine M K Choi
Research25 Jul 2016
Nature Medicine

Volume: 22, P: 1002-1012
Mitochondrial Dysfunction in Aged Macrophages and Lung during Primary Streptococcus pneumoniae Infection is Improved with Pirfenidone

Maria Plataki
Soo Jung Cho
Heather W. Stout-Delgado
ResearchOpen Access30 Jan 2019
Scientific Reports

Volume: 9, P: 1-16
Cytokine signatures of end organ injury in COVID-19

Luis G. Gómez-Escobar
Katherine L. Hoffman
Edward J. Schenck
ResearchOpen Access15 Jun 2021
Scientific Reports

Volume: 11, P: 1-15