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Missing steps uncovered in a pathway plants use to produce the defence molecule salicylic acid

A long-standing mystery about a pathway that makes a key defence molecule in various valuable crop plants is finally solved.

Jiyeon Hyun
Heejin Yoo
News & Views23 Jul 2025
Nature

Volume: 645, P: 48-50
An alternative pathway contributes to phenylalanine biosynthesis in plants via a cytosolic tyrosine:phenylpyruvate aminotransferase

Plants primarily synthesize phenylalanine in plastids via arogenate. Here, Yoo et al. provide evidence that petunia flowers also employ an alternative microbial-like pathway to synthesize phenylalanine that is partially localized in the cytosol and interconnected with tyrosine catabolism.

Heejin Yoo
Joshua R. Widhalm
Natalia Dudareva
Research25 Nov 2013
Nature Communications

Volume: 4, P: 1-11
Prephenate aminotransferase directs plant phenylalanine biosynthesis via arogenate

In addition to its incorporation into proteins, phenylalanine serves as an important precursor for natural products and components of the plant cell wall. The identification of the last gene in phenylalanine biosynthesis explains why flux in this pathway traffics through an arogenate intermediate in plants.

Hiroshi Maeda
Heejin Yoo
Natalia Dudareva
Research21 Nov 2010
Nature Chemical Biology

Volume: 7, P: 19-21
BAFF-neutralizing interaction of belimumab related to its therapeutic efficacy for treating systemic lupus erythematosus

Blocking B-cell activating factor (BAFF), an important soluble factor for B-cell responses, with specific antibodies is approved for treating autoimmune disorders. Here the authors show, with structural data, that antibody-BAFF interactions not only interrupt BAFF–receptor-binding, but also induce the formation of a less active BAFF polymer.

Woori Shin
Hyun Tae Lee
Yong-Seok Heo
ResearchOpen Access23 Mar 2018
Nature Communications

Volume: 9, P: 1-11
Kv7/KCNQ potassium channels in cortical hyperexcitability and juvenile seizure-related death in Ank2-mutant mice

Seizures can occur in autism spectrum disorders (ASD). Here, the authors report that mice lacking the ASD related Ank2 gene show abnormal behaviours, and juvenile seizure related death, through impaired Kv7 potassium channel function.

Hyoseon Oh
Suho Lee
Eunjoon Kim
ResearchOpen Access15 Jun 2023
Nature Communications

Volume: 14, P: 1-20
Prediction model for early graft failure after liver transplantation using aspartate aminotransferase, total bilirubin and coagulation factor

Jinsoo Rhu
Jong Man Kim
Jae-Won Joh
ResearchOpen Access18 Jun 2021
Scientific Reports

Volume: 11, P: 1-9
Identification of a plastidial phenylalanine exporter that influences flux distribution through the phenylalanine biosynthetic network

Phenylalanine is synthesized in plant chloroplasts and is then exported to the cytosol, where it is a precursor for various secondary metabolites. Here, the authors identify PhpCAT as a plastid phenylalanine transporter required to maintain metabolic flux in petunia.

Joshua R. Widhalm
Michael Gutensohn
Natalia Dudareva
ResearchOpen Access10 Sept 2015
Nature Communications

Volume: 6, P: 1-11
Correction: Adnp-mutant mice with cognitive inflexibility, CaMKIIα hyperactivity, and synaptic plasticity deficits

Heejin Cho
Taesun Yoo
Eunjoon Kim
Amendments and CorrectionsOpen Access21 Jul 2023
Molecular Psychiatry

Volume: 28, P: 3563
Global translational reprogramming is a fundamental layer of immune regulation in plants

Global translatome analysis shows that plants also modify their translational output—independently of the changes in transcriptional output—to establish pattern-triggered immunity.

Guoyong Xu
George H. Greene
Xinnian Dong
Research17 May 2017
Nature

Volume: 545, P: 487-490
Integrative analysis of AT classification, plasma biomarkers, and cognitive trajectories across diverse dementia syndromes

Jihwan Yun
Min Young Chun
Hyemin Jang
ResearchOpen Access11 Dec 2025
Scientific Reports

Volume: 16, P: 1-13
Adnp-mutant mice with cognitive inflexibility, CaMKIIα hyperactivity, and synaptic plasticity deficits

Heejin Cho
Taesun Yoo
Eunjoon Kim
ResearchOpen Access26 Jun 2023
Molecular Psychiatry

Volume: 28, P: 3548-3562
Unveiling genetic variants for age-related sarcopenia by conducting a genome-wide association study on Korean cohorts

Heejin Jin
Hyun Ju Yoo
Je Hyun Seo
ResearchOpen Access03 Mar 2022
Scientific Reports

Volume: 12, P: 1-12
Muscle coordination and recruitment during squat assistance using a robotic ankle–foot exoskeleton

Hyeongkeun Jeong
Parian Haghighat
Myunghee Kim
ResearchOpen Access24 Jan 2023
Scientific Reports

Volume: 13, P: 1-10
Distinct spatiotemporal patterns of cortical thinning in Alzheimer’s disease-type cognitive impairment and subcortical vascular cognitive impairment

Using the SuStaIn model on 1,338 individuals, this study reveals distinct cortical atrophy in Alzheimer’s disease-type cognitive impairment and subcortical vascular cognitive impairment, revealing varying cognitive decline trajectories.

Jinhee Kim
Jonghoon Kim
Sang Won Seo
ResearchOpen Access17 Feb 2024
Communications Biology

Volume: 7, P: 1-10
Dysregulated miRNA in a cancer-prone environment: A study of gastric non-neoplastic mucosa

Binnari Kim
Jiryeon Jang
Kyoung-Mee Kim
ResearchOpen Access20 Apr 2020
Scientific Reports

Volume: 10, P: 1-9

Search

Missing steps uncovered in a pathway plants use to produce the defence molecule salicylic acid

An alternative pathway contributes to phenylalanine biosynthesis in plants via a cytosolic tyrosine:phenylpyruvate aminotransferase

Prephenate aminotransferase directs plant phenylalanine biosynthesis via arogenate

BAFF-neutralizing interaction of belimumab related to its therapeutic efficacy for treating systemic lupus erythematosus

Kv7/KCNQ potassium channels in cortical hyperexcitability and juvenile seizure-related death in Ank2-mutant mice

Prediction model for early graft failure after liver transplantation using aspartate aminotransferase, total bilirubin and coagulation factor

Identification of a plastidial phenylalanine exporter that influences flux distribution through the phenylalanine biosynthetic network

Correction: Adnp-mutant mice with cognitive inflexibility, CaMKIIα hyperactivity, and synaptic plasticity deficits

Global translational reprogramming is a fundamental layer of immune regulation in plants

Integrative analysis of AT classification, plasma biomarkers, and cognitive trajectories across diverse dementia syndromes

Adnp-mutant mice with cognitive inflexibility, CaMKIIα hyperactivity, and synaptic plasticity deficits

Unveiling genetic variants for age-related sarcopenia by conducting a genome-wide association study on Korean cohorts

Muscle coordination and recruitment during squat assistance using a robotic ankle–foot exoskeleton

Distinct spatiotemporal patterns of cortical thinning in Alzheimer’s disease-type cognitive impairment and subcortical vascular cognitive impairment

Dysregulated miRNA in a cancer-prone environment: A study of gastric non-neoplastic mucosa

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