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Showing 1–5 of 5 results
Advanced filters: Author: Heike Wollmann Clear advanced filters

  • The oocyte-to-embryo transition marks the beginning of development but the mechanisms underlying this process are incompletely described. Here they show that PRDM10 activates Septin11 and is required for progression through the oocyte-to-embryo transition.

    • Michelle K. Y. Seah
    • Brenda Y. Han
    • Daniel M. Messerschmidt
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13

  • The transcriptional regulator PRDM15 is expressed at low levels in normal tissues but overexpressed in B-cell lymphomas. Here, the authors show that PRDM15 depletion does not affect adult somatic cell homeostasis but leads to a metabolic crisis which impairs B-cell lymphomagenesis.

    • Slim Mzoughi
    • Jia Yi Fong
    • Ernesto Guccione
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • Ernesto Guccione and colleagues report that the transcription factor PRDM15 regulates naive pluripotency in mouse embryos and embryonic stem cells and in derivation of mouse and human iPSCs. They further show that PRDM15 promotes WNT signaling and inhibits MAPK–ERK signaling by directly regulating the expression of R-spondin1 and Sprouty1, respectively.

    • Slim Mzoughi
    • Jingxian Zhang
    • Ernesto Guccione
    Research
    Nature Genetics
    Volume: 49, P: 1354-1363

  • Vin Yee Chung et al. identify differentially methylated CpG sites in the promoters of epithelial genes and GRHL2 binding sites in ovarian cancer cells during the epithelial–mesenchymal transition. They find that GRHL2 knockdown or overexpression affects methylation, suggesting a role for this transcription factor in epigenetic remodeling.

    • Vin Yee Chung
    • Tuan Zea Tan
    • Ruby Yun-Ju Huang
    ResearchOpen Access
    Communications Biology
    Volume: 2, P: 1-15