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Showing 1–3 of 3 results
Advanced filters: Author: Helen Carrasco Hope Clear advanced filters

  • Vannini and colleagues report that an age-associated decline in nicotinamide adenine dinucleotide levels is associated with mitochondrial dysfunction and reduced antitumor efficacy of chimeric antigen receptor T cells derived from older adults.

    • Helen Carrasco Hope
    • Jana de Sostoa
    • Nicola Vannini
    ResearchOpen Access
    Nature Cancer
    Volume: 6, P: 1524-1536

  • Urolithin A (UA) is a gut microbiome-derived metabolite that has been therapeutically explored in aging-related diseases and exerts its benefits in part through effects on mitochondria. Here Girotra, Chiang and colleagues show that UA administration boosts mitochondrial recycling in hematopoietic stem cells and reverses aging features in both the hematopoietic and immune systems.

    • Mukul Girotra
    • Yi-Hsuan Chiang
    • Nicola Vannini
    Research
    Nature Aging
    Volume: 3, P: 1057-1066