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Showing 1–5 of 5 results
Advanced filters: Author: Helen M. Lazear Clear advanced filters

  • Many human antibodies that neutralize Zika virus recognize quaternary epitopes on the envelope (E) protein. Here, Metz et al. engineer stable recombinant homodimers of Zika virus E protein and show that it induces neutralizing antibodies in mice that recognize similar epitopes as human antibodies from Zika infected people.

    • Stefan W. Metz
    • Ashlie Thomas
    • Aravinda M. de Silva
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-7

  • Biomolecules morph between conformations with distinct lifetimes essential for function. This study reveals the cores of flaviviral RNAs stay stable up to ten million times longer than canonical base pairs to effectively resist exonuclease digestion.

    • Rhese D. Thompson
    • Derek L. Carbaugh
    • Qi Zhang
    Research
    Nature Chemical Biology
    Volume: 21, P: 1021-1029

  • The placenta forms the foremost barrier that protects the developing fetus during pregnancy in eutherian organisms. However, diverse pathogens such asToxoplasma gondii, rubella virus and cytomegalovirus can breach this barrier. In this Opinion article, Coyne and Lazear review mechanisms of vertical transmission, with a focus on the current Zika virus epidemic.

    • Carolyn B. Coyne
    • Helen M. Lazear
    Reviews
    Nature Reviews Microbiology
    Volume: 14, P: 707-715