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Showing 1–13 of 13 results
Advanced filters: Author: Helen S. Bateup Clear advanced filters

  • Tuberous Sclerosis Complex (TSC) is a neurodevelopmental disorder caused by mutations in the TSC1 or TSC2 genes, which negatively regulate mTORC1 signalling. Here the authors selectively delete Tsc1 from dopamine neurons in mice and find impairments in striatal dopamine release that are sufficient to reduce cognitive flexibility.

    • Polina Kosillo
    • Natalie M. Doig
    • Helen S. Bateup
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-19

  • CRISPR–Cas9-mediated gene editing of TSC1 and TSC2 in human pluripotent stem cells is used to investigate the contribution of tuberous sclerosis complex–mechanistic target of rapamycin complex 1 signaling to human neural development in two-dimensional monolayer and three-dimensional spheroid models of the neurodevelopmental disorder tuberous sclerosis complex.

    • John D. Blair
    • Dirk Hockemeyer
    • Helen S. Bateup
    Research
    Nature Medicine
    Volume: 24, P: 1568-1578

  • Calcium signals are typically traced through electrophysical, optical and genetic methods. Here the authors report the development of Cal-ID, a calcium-dependent protein proximity labeling tool that can be used to record elevated calcium levels in cells.

    • J. Wren Kim
    • Adeline J. H. Yong
    • Nicholas T. Ingolia
    Research
    Nature Chemical Biology
    Volume: 20, P: 894-905

  • STING is considered central to antiviral immunity via induction of type 1 interferons, but can also activate autophagy. Here the authors made two mice with different STING mutations that differentially affect these antiviral responses, and surprisingly show that inhibiting STING-dependent type 1 interferon production does not affect susceptibility to HSV-1 infection.

    • Lívia H. Yamashiro
    • Stephen C. Wilson
    • Russell E. Vance
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • The nomenclature for human multicellular models of nervous system development and disease, including organoids, assembloids and transplants, is discussed and a consensus framework is presented.

    • Sergiu P. Pașca
    • Paola Arlotta
    • Flora M. Vaccarino
    Reviews
    Nature
    Volume: 609, P: 907-910

  • On April 13, the neuroscience community lost a remarkable scientist and true humanitarian. Paul Greengard, co-recipient of the Nobel Prize in Physiology or Medicine in 2000, Vincent Astor Professor and head of the Laboratory of Molecular and Cellular Neuroscience at the Rockefeller University in New York City, died of an apparent heart attack at age 93. Paul will be remembered for his seminal contributions to neuroscience, for pioneering the field of neuronal signal transduction and for training hundreds of neuroscientists. For anyone who knew Paul it will come as no surprise that up until a few hours before his death, Paul was doing what he liked the best: working on a scientific manuscript.

    • Helen S. Bateup
    • Myriam Heiman
    • Anne Schaefer
    Comments & Opinion
    Nature Neuroscience
    Volume: 22, P: 1203-1204

  • DARPP-32 phosphorylation is crucial to the actions of both psychostimulant and antipsychotic drugs. By using BAC transgenic mice to tag DARPP32 selectively in either striatonigral or striatopallidal neurons, the authors show that cocaine (a psychostimulant) and haloperidol (an antipsychotic) exert different effects on DARPP-32 in these two neuronal populations. This may help explain the opposing behavioral effects of these drugs.

    • Helen S Bateup
    • Per Svenningsson
    • Paul Greengard
    Research
    Nature Neuroscience
    Volume: 11, P: 932-939

  • The BRAIN Initiative Cell Census Network has constructed a multimodal cell census and atlas of the mammalian primary motor cortex in a landmark effort towards understanding brain cell-type diversity, neural circuit organization and brain function.

    • Edward M. Callaway
    • Hong-Wei Dong
    • Susan Sunkin
    ResearchOpen Access
    Nature
    Volume: 598, P: 86-102

  • An international group of neuroscience researchers presents a framework for experimental designs for research using neural organoids and assembloids to study human development, evolution and disease.

    • Sergiu P. Pașca
    • Paola Arlotta
    • Tracy Young-Pearse
    Reviews
    Nature
    Volume: 639, P: 315-320

  • Single-cell or single-nucleus RNA-sequencing experiments form a basis for biological insights about cell types and states, but they require orthogonal experiments to confirm the functional relevance of their findings. Here the authors discuss options to support such findings and their challenges.

    • Marco Colonna
    • Genevieve Konopka
    • Naomi Habib
    Reviews
    Nature Neuroscience
    Volume: 27, P: 2310-2325