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Showing 1–7 of 7 results
Advanced filters: Author: Helen Scharfman Clear advanced filters

  • Mossy cells are a major subpopulation of glutamatergic principal neurons within the dentate gyrus; however, their roles in hippocampal circuitry are poorly understood. Scharfman describes how new techniques to probe mossy cell function are shedding light on their contribution to hippocampal function and behaviour.

    • Helen E. Scharfman
    Reviews
    Nature Reviews Neuroscience
    Volume: 17, P: 562-575

  • Aberrant hippocampal neurogenesis often occurs after acute seizures that produce epilepsy and cognitive impairment but the role of neurogenesis in the development of epilepsy is unclear. Here the authors suppress adult neurogenesis in mice preceding seizures and show that it reduces subsequent chronic seizure frequency and epilepsy-associated cognitive decline.

    • Kyung-Ok Cho
    • Zane R. Lybrand
    • Jenny Hsieh
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-13

  • Hormonal changes during the estrous cycle have profound effects on synaptic transmission, from altering the density of synapses to changing receptor composition. A new paper shows that neurons express different subsets of GABAA receptor subunits during different phases of the estrous cycle, and that this alters tonic inhibition, seizure susceptibility and anxiety in female mice.

    • Kevin Staley
    • Helen Scharfman
    News & Views
    Nature Neuroscience
    Volume: 8, P: 697-699

  • Various theories exist for the function of the dentate gyrus in learning and memory. In this Perspective article, Rangel and colleagues compare a number of these theories and discuss how they may be further tested to develop a better understanding of dentate gyrus function.

    • Mia Borzello
    • Steve Ramirez
    • Lara M. Rangel
    Reviews
    Nature Reviews Neuroscience
    Volume: 24, P: 502-517