Sustained consumption of high amounts of nutrients replete with appetite-enhancing pro-oxidant advanced glycation endproducts (AGEs) is a crucial link between a positive energy balance and deleterious outcomes, such as insulin resistance and inflammation, and restriction of AGEs in nutrients improves both conditions. This Review focuses on AGEs as novel initiators of oxidative stress that precede rather than result from diabetes mellitus and illustrates the potential therapeutic gains from AGE restriction as an effective, cost-efficient strategy.
- Helen Vlassara
- Gary E. Striker
