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Showing 1–9 of 9 results
Advanced filters: Author: Helena Santos-Rosa Clear advanced filters

  • Epigenetic traits can persist across generations through small RNAs and chromatin marks. Here, the authors show that SET-24, a non-enzymatic SET protein, partners with HCF-1 to maintain RNAi silencing and sustain chromatin states and small RNA populations in C. elegans.

    • Chenming Zeng
    • Giulia Furlan
    • Eric A. Miska
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-21

  • Here the authors show thatMETTL9 enzyme sustains neural development in vertebrates by maintaining the secretory pathway, mainly independently of METTL9 catalytic activity. METTL9 loss in cells leads to Golgi fragmentation.

    • Azzurra Codino
    • Luca Spagnoletti
    • Luca Pandolfini
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-29

  • Methylation at particular residues on histone tails has been associated with various functions and, in the case of dimethylated histone H3 arginine 2 (H3R2), cross-talk with methylation of a nearby lysine has been shown to be linked to transcriptional repression. Budding yeast monomethylated H3R2 is now shown to be associated with active loci and involved in activation of meiotic genes upon induction of sporulation.

    • Antonis Kirmizis
    • Helena Santos-Rosa
    • Tony Kouzarides
    Research
    Nature Structural & Molecular Biology
    Volume: 16, P: 449-451

  • Mass spectrometry (MS) enables identification of modified RNA residues, but high-throughput processing is currently a bottleneck. Here, the authors present a free and open-source database search engine for RNA MS data to facilitate reliable identification of modified RNA sequences.

    • Samuel Wein
    • Byron Andrews
    • Hendrik Weisser
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12

  • Nucleosome stability can influence gene expression and is regulated by nucleosome-positioning sequences, histone chaperones, remodeling complexes, post-translational modifications and histone variants. Now, histone H3 tail clipping has been added to the list. Kouzarides and co-workers have identified a serine endopeptidase in yeast that cleaves H3 after Ala21 and shows a preference for H3 tails with repressive modifications. In vivo, this occurs at the promoters of induced genes and precedes histone eviction when genes become fully active.

    • Helena Santos-Rosa
    • Antonis Kirmizis
    • Tony Kouzarides
    Research
    Nature Structural & Molecular Biology
    Volume: 16, P: 17-22

  • Methylation of histone H3 on residue Lys4 (H3K4) contributes to transcription activation. Now it is shown that in budding yeast, an adjacent modification, methylated Arg2, can inhibit H3K4 methylation by preventing the binding of a methyl transferase complex.

    • Antonis Kirmizis
    • Helena Santos-Rosa
    • Tony Kouzarides
    Research
    Nature
    Volume: 449, P: 928-932