How the nuclear exosome is targeted to nuclear RNA substrates is poorly understood. An affinity-capture MS approach and functional analyses now demonstrate a physical and functional connection between the human exosome and the cap-binding complex (CBC). A CBC-containing complex was found to promote transcription termination of several RNA types, thus suggesting a direct link to exosomal RNA degradation.
- Peter Refsing Andersen
- Michal Domanski
- Torben Heick Jensen
