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Showing 1–3 of 3 results
Advanced filters: Author: Helene Le Buanec Clear advanced filters

  • Le Buanec, Schiavon, Merandet et al. study the underlying immune responses for the elevation of IFNα that occurs during an antiretroviral treatment interruption in HIV patients. IFNα mediated induction of CCR5 is shown to promote pathogenic phenotype, while elite controllers avoid this by an unknown genetic factor or a low inoculum infection.

    • Hélène Le Buanec
    • Valérie Schiavon
    • Robert C. Gallo
    ResearchOpen Access
    Communications Medicine
    Volume: 4, P: 1-13

  • Le Buanec et al. compared distribution and frequency of cell markers associated with immune dysfunction between HIV elite controllers (EC) and untreated non-EC. They demonstrate that untreated HIV-infected individuals exhibit structurally and functionally impaired immune subsets, as a consequence of excessive levels of serum IFNα.

    • Hélène Le Buanec
    • Valérie Schiavon
    • Daniel Zagury
    ResearchOpen Access
    Communications Medicine
    Volume: 4, P: 1-12

  • Recessive dystrophic epidermolysis bullosa (RDEB) is a severe blistering condition caused by pathogenic variants in the COL7A1 gene and may present with different disease endotypes. In this study, the authors characterise a cohort of RDEB adults to highlight variations in immune cell phenotypes and metabolic profiles, particularly in T cells and NK cells.

    • Nell Hirt
    • Enzo Manchon
    • Reem Al-Daccak
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18