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Showing 1–9 of 9 results
Advanced filters: Author: Helge Großhans Clear advanced filters

  • Interaction of the RNase XRN2 with PAXT-1 and related XTB domain–containing proteins is important for XRN2 function in vivo and probably serves to increase XRN2 stability in the absence of substrate.

    • Hannes Richter
    • Iskra Katic
    • Helge Großhans
    Research
    Nature Structural & Molecular Biology
    Volume: 23, P: 164-171

  • Animals must reach the correct size during development, despite stochastic differences in their growth rate. Here, Stojanovski et al. show that a coupling of growth and development by an oscillatory timer buffers fluctuations in the growth of the nematode C. elegans to ensure its correct size.

    • Klement Stojanovski
    • Helge Großhans
    • Benjamin D. Towbin
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14

  • MicroRNAs have important roles in shaping gene expression profiles during development, repressing target messenger RNAs to control various biological processes. The degradation of mature microRNAs in the nematode Caenorhabditis elegans, mediated by the 5′→3′ exoribonuclease XRN-2, is now found to affect functional microRNA homeostasis in vivo.

    • Saibal Chatterjee
    • Helge Großhans
    Research
    Nature
    Volume: 461, P: 546-549

  • Argonaute proteins are key effectors in the microRNA pathway. Here, the authors show that the conserved peptidase DPF-3 regulates Argonautes in C. elegans, and that loss of dpf-3 restores function and fitness in animals lacking the microRNA Argonaute ALG-1.

    • Louis-Mathieu Harvey
    • Pierre-Marc Frédérick
    • Martin J. Simard
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • Molecular cell biology has long been dominated by a protein-centric view. But the emergence of small, non-coding RNAs challenges this perception. These plentiful RNAs regulate gene expression at different levels, and have essential roles in health and disease.

    • Helge Großhans
    • Witold Filipowicz
    Comments & Opinion
    Nature
    Volume: 451, P: 414-416

  • The C. elegans LIN-41 and its homologs, including human TRIM71/LIN41, contain the RNA binding NHL domain. Here the authors combine computational analysis, structural biology and in vivo studies, to explain how these proteins bind RNA and how rapid evolution of NHL domains resulted in different solutions to RNA recognition.

    • Pooja Kumari
    • Florian Aeschimann
    • Rafal Ciosk
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-15

  • Transcripts with highly complementary sequences can target microRNAs (miRNAs) for degradation, but the physiological relevance of target-directed miRNA degradation (TDMD) has remained unclear. Bitetti et al. now identify a conserved vertebrate RNA that induces TDMD in the cerebellum of zebrafish and mouse to promote wild-type animal behaviors.

    • Manuel de la Mata
    • Helge Großhans
    News & Views
    Nature Structural & Molecular Biology
    Volume: 25, P: 195-197

  • MicroRNA targets predicted by a variety of computational tools can be validated using a quantitative targeted proteomics approach, using stable isotope labeling and selected reaction monitoring mass spectrometry. The authors used this method to confirm predicted let-7 and miR-58 targets in Caenorhabditis elegans.

    • Marko Jovanovic
    • Lukas Reiter
    • Michael O Hengartner
    Research
    Nature Methods
    Volume: 7, P: 837-842