Dynein is a molecular motor involved in many cellular functions. The motor domain of dynein contains six AAA+ domains forming a ring that interacts with the motile linker domain. The structure of yeast dynein motor domain crystallized without nucleotides is now presented at 3.3-Å resolution and shows the specific contacts between linker and ring, with nucleotide interactions at the different AAA+ domains revealed by soaking experiments.
- Helgo Schmidt
- Emma S Gleave
- Andrew P Carter
