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Showing 1–11 of 11 results
Advanced filters: Author: Helmut Sies Clear advanced filters

  • In 1923, Otto Warburg published his landmark study, in which he described his seminal observations related to metabolic shifts in cancer, often referred to as the Warburg effect. His work laid the foundation for an understanding of how metabolic reconfiguration contributes to cancer onset and progression. Several researchers in the field share their thoughts on what this discovery means to them and how it has inspired their scientific journey.

    • Craig B. Thompson
    • Karen H. Vousden
    • Caroline R. Bartman
    Reviews
    Nature Metabolism
    Volume: 5, P: 1840-1843

  • Cell metabolism relies on redox reactions to harness energy for life. Cells need to sense and regulate their internal redox state, typically with cysteine thiols. At plastid origin, cysteine residue frequency increased in the diatom genome lineage, an evolutionary redox footprint preserved in plant DNA.

    • William F. Martin
    • Helmut Sies
    News & Views
    Nature Plants
    Volume: 3, P: 1-2

  • Oxidation–reduction (redox) reactions involving reactive oxygen, nitrogen and sulfur species are vital for life, but excessive oxidant levels contribute to ageing and diseases. This Review explores cellular dynamics of redox homeostasis, such as responses to oxidative and reductive stresses and intracellular and intercellular redox communication pathways.

    • Helmut Sies
    • Ryan J. Mailloux
    • Ursula Jakob
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 25, P: 701-719

  • Reactive oxygen species (ROS) comprise a wide variety of oxidant molecules with vastly different properties and biological functions in physiology and in disease. Approaches to characterize oxidants in the in vivo context and identify their specific cellular targets will be required to understand and control the pathophysiological activities of ROS.

    • Helmut Sies
    • Vsevolod V. Belousov
    • Christine Winterbourn
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 23, P: 499-515

  • Reactive oxygen species (ROS) were originally associated with cellular damage and disease. However, ROS, notably hydrogen peroxide, at low physiological levels also engage in physiological signalling, supporting cellular responses and adaptation to changing environments and stress. Accordingly, controlling specific ROS-mediated signalling pathways offers new perspectives for a more refined redox medicine.

    • Helmut Sies
    • Dean P. Jones
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 21, P: 363-383