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Showing 1–2 of 2 results
Advanced filters: Author: Hemant K. Prajapati Clear advanced filters
  • Chromatin structure is thought to regulate transcription factor access by modulating DNA accessibility. Here, the authors show that in living human cells, euchromatin and heterochromatin are fully accessible, while centromeric chromatin remains partially inaccessible.

    • Hemant K. Prajapati
    • Zhuwei Xu
    • David J. Clark
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11
  • The authors measure the accessibility of the yeast genome using DNA methylases. They show that the genome is globally accessible in living cells, except for centromeres and silenced loci, unlike in isolated nuclei, in which accessibility is strictly limited.

    • Hemant K. Prajapati
    • Peter R. Eriksson
    • David J. Clark
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 32, P: 247-256