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Showing 1–3 of 3 results
Advanced filters: Author: Hengqian Ren Clear advanced filters

  • Ribosomally synthesized and post-translationally modified peptides (RiPPs) can have vast structural diversity and biological functions enabled by disparate post-translational modifications (PTMs). However, unconventional PTMs derived from non-RiPP biosynthesis are rarely reported. Now a class of lipopeptides featuring a distinct fatty-acyl-modified N terminus and the responsible RiPP/fatty-acid hybrid biosynthetic machinery have been characterized.

    • Hengqian Ren
    • Chunshuai Huang
    • Huimin Zhao
    Research
    Nature Chemistry
    Volume: 16, P: 1320-1329

  • RiPP discovery has expanded the scope of post-translational modification chemistry, but genome mining of RiPP classes remains an unsolved challenge. Here, the authors employed bioinformatics and synthetic biology approaches to discover and characterize an unknown class of RiPPs, defined by an unusual amino-modified C-terminus.

    • Hengqian Ren
    • Shravan R. Dommaraju
    • Huimin Zhao
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13

  • Ribosomally synthesized and post-translationally modified peptides are a source of antimicrobials. Here, the authors report a platform for the rapid evaluation and characterization of biosynthetic gene clusters that enables the identification of 30 structurally diverse modified peptides, including three showing antimicrobial activities.

    • Richard S. Ayikpoe
    • Chengyou Shi
    • Huimin Zhao
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15