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Showing 1–6 of 6 results

Advanced filters: Author: Henri Brunengraber Clear advanced filters

Contribution of Lactose or Lactulose Fermentation to Butyric Acid Production in the Piglet

C Lawrence Kien
Jung C Chang
Henri Brunengraber
Research01 Apr 1999
Pediatric Research

Volume: 45, P: 113
Increased glucose availability sensitizes pancreatic cancer to chemotherapy

Response to chemotherapy in patients with pancreatic ductal adenocarcinoma (PDAC) is often limited. Here, the authors report improved response to chemotherapy in PDAC patients with hyperglycaemia and investigate the underlying mechanism via glucose-mediated disruption of redox metabolism

Ali Vaziri-Gohar
Jonathan J. Hue
Jordan M. Winter
ResearchOpen Access28 Jun 2023
Nature Communications

Volume: 14, P: 1-13
Colorectal cancers utilize glutamine as an anaplerotic substrate of the TCA cycle in vivo

Yiqing Zhao
Xuan Zhao
Zhenghe Wang
ResearchOpen Access16 Dec 2019
Scientific Reports

Volume: 9, P: 1-9
Hyperoxia induces glutamine-fuelled anaplerosis in retinal Müller cells

Prematurely born babies need extra oxygen to survive, but this can cause damage to the eyes and lead to infant blindness. Here the authors show that this hyperoxia changes the metabolism of Müller cells in the retina such that they use up, rather than produce, glutamine and secrete excess ammonium.

Charandeep Singh
Vincent Tran
Jonathan E. Sears
ResearchOpen Access09 Mar 2020
Nature Communications

Volume: 11, P: 1-11
Limited nutrient availability in the tumor microenvironment renders pancreatic tumors sensitive to allosteric IDH1 inhibitors

Winter and colleagues demonstrate that metabolic adaptation to nutrient stress in the tumor microenvironment of pancreatic cancer leads to a dependency on IDH1, which is therapeutically actionable regardless of IDH1 mutation status.

Ali Vaziri-Gohar
Joel Cassel
Jordan M. Winter
ResearchOpen Access09 Jun 2022
Nature Cancer

Volume: 3, P: 852-865
Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer

Cancer cells rely on glutamine to replenish the TCA cycle. Here, the authors show that oncogenic PIK3CAmutations drive this metabolic rewiring in colorectal cancer cells by up-regulating glutamate pyruvate transaminase expression, thus increasing sensitivity to glutamine starvation.

Yujun Hao
Yardena Samuels
Zhenghe Wang
ResearchOpen Access20 Jun 2016
Nature Communications

Volume: 7, P: 1-13