Nature Search

Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus

Henriette van Praag
Gerd Kempermann
Fred H. Gage
Research01 Mar 1999
Nature Neuroscience

Volume: 2, P: 266-270
Functional neurogenesis in the adult hippocampus

Henriette van Praag
Alejandro F. Schinder
Fred H. Gage
Research28 Feb 2002
Nature

Volume: 415, P: 1030-1034
TAGing APP constrains neurogenesis

The cell adhesion molecule TAG1 has been identified as the ligand that induces β-amyloid precursor protein (APP) processing and signalling, resulting in the inhibition of neurogenesis. These findings demonstrate a critical role of TAG1–APP signalling in brain development and suggest the potential involvement of TAG1 in adult neuroplasticity and pathogenesis of Alzheimer's disease.

Mark P. Mattson
Henriette van Praag
News & Views01 Mar 2008
Nature Cell Biology

Volume: 10, P: 249-250
Reply to ‘Lactate as a major myokine and exerkine’

Lisa S. Chow
Robert E. Gerszten
Michael Snyder
Correspondence01 Aug 2022
Nature Reviews Endocrinology

Volume: 18, P: 713
Topoisomerase 3β knockout mice show transcriptional and behavioural impairments associated with neurogenesis and synaptic plasticity

Topoisomerase 3β (Top3β) solves topological stress in DNA or RNA metabolism and its mutations are linked to mental disorders. Here, the authors describe transcriptional and behavioural impairments in Top3β-knockout mice and show that these are linked to impaired neurogenesis and synaptic plasticity.

Yuyoung Joo
Yutong Xue
Weidong Wang
ResearchOpen Access19 Jun 2020
Nature Communications

Volume: 11, P: 1-18
Neural consequences of enviromental enrichment

Henriette van Praag
Gerd Kempermann
Fred H. Gage
Reviews01 Dec 2000
Nature Reviews Neuroscience

Volume: 1, P: 191-198
Reduced mitochondrial fusion and Huntingtin levels contribute to impaired dendritic maturation and behavioral deficits in Fmr1-mutant mice

Shen et al. show that FMRP promotes mitochondrial fusion through HTT. FMRP loss caused fragmented mitochondria and oxidative stress in immature neurons, and enhancing mitochondrial fusion rescued neuronal and behavioral deficits in Fmr1-mutant mice.

Minjie Shen
Feifei Wang
Xinyu Zhao
Research11 Feb 2019
Nature Neuroscience

Volume: 22, P: 386-400
Stage-specific functions of Semaphorin7A during adult hippocampal neurogenesis rely on distinct receptors

The functions of semaphorins in the adult brain are poorly understood. Here the authors show that Sema7A carries out stage-specific functions in the adult hippocampus via differential receptor usage; in progenitor cells, Sema7A inhibits proliferation via acting on PlexinC1, whereas in adult-born neurons, it promotes dendrite growth through β1-integrins.

Bart C. Jongbloets
Suzanne Lemstra
R. Jeroen Pasterkamp
ResearchOpen Access10 Mar 2017
Nature Communications

Volume: 8, P: 1-17
Synapse formation on neurons born in the adult hippocampus

Nicolas Toni
E Matthew Teng
Fred H Gage
Research07 May 2007
Nature Neuroscience

Volume: 10, P: 727-734
Monosynaptic inputs to new neurons in the dentate gyrus

Adult neurogenesis in the mammalian brain is implicated in the storage and processing of memories. Vivaret al.label afferents to new dentate gyrus granule cells and find that they receive direct input from the perirhinal and lateral entorhinal cortex and that these inputs enable spatial pattern separation.

Carmen Vivar
Michelle C. Potter
Henriette van Praag
Research02 Oct 2012
Nature Communications

Volume: 3, P: 1-11
Exerkines in health, resilience and disease

Exerkines are signalling moieties that are released in response to acute and/or chronic exercise that exert their effects through endocrine, paracrine and/or autocrine pathways. This Review summarizes the importance and current state of exerkine research, prevailing challenges and future directions.

Lisa S. Chow
Robert E. Gerszten
Michael P. Snyder
Reviews18 Mar 2022
Nature Reviews Endocrinology

Volume: 18, P: 273-289
Steps towards standardized quantification of adult neurogenesis

Adult neurogenesis is involved in several physiological and pathological processes, however standardization for the quantification of new born neurons is lacking. Here, the authors provide guidance to improve reproducibility and rigour in cell quantification.

Xinyu Zhao
Henriette van Praag
ReviewsOpen Access26 Aug 2020
Nature Communications

Volume: 11, P: 1-10
Running reorganizes the circuitry of one-week-old adult-born hippocampal neurons

Nirnath Sah
Benjamin D. Peterson
Henriette van Praag
ResearchOpen Access07 Sept 2017
Scientific Reports

Volume: 7, P: 1-15
An exercise infusion benefits brain function

Alejandro Pinto
Henriette van Praag
Research Highlights24 Jan 2022
Cell Research

Volume: 32, P: 223-224

Search

Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus

Functional neurogenesis in the adult hippocampus

TAGing APP constrains neurogenesis

Reply to ‘Lactate as a major myokine and exerkine’

Topoisomerase 3β knockout mice show transcriptional and behavioural impairments associated with neurogenesis and synaptic plasticity

Neural consequences of enviromental enrichment

Reduced mitochondrial fusion and Huntingtin levels contribute to impaired dendritic maturation and behavioral deficits in Fmr1-mutant mice

Stage-specific functions of Semaphorin7A during adult hippocampal neurogenesis rely on distinct receptors

Synapse formation on neurons born in the adult hippocampus

Monosynaptic inputs to new neurons in the dentate gyrus

Exerkines in health, resilience and disease

Steps towards standardized quantification of adult neurogenesis

Running reorganizes the circuitry of one-week-old adult-born hippocampal neurons

An exercise infusion benefits brain function

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