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Showing 1–3 of 3 results
Advanced filters: Author: Henrik Frydenlund Hansen Clear advanced filters

  • Small interfering RNAs (siRNAs) can be systemically administered in non-human primates and significantly reduce expression from the mRNA against which they are directed. A therapeutic effect can also be achieved by targeting a microRNA (miRNA). A modified oligonucleotide directed against miR-122 was administered to monkeys, resulting in a reduction in serum cholesterol without detectable toxicity.

    • Joacim Elmén
    • Morten Lindow
    • Sakari Kauppinen
    Research
    Nature
    Volume: 452, P: 896-899

  • Sakari Kauppinen and colleagues report a method for silencing miRNA families in vivo. They find that seed-targeting 8-mer LNA oligonucleotides, termed tiny LNAs, can lead to long-term miRNA silencing in normal tissues and breast tumors in mice.

    • Susanna Obad
    • Camila O dos Santos
    • Sakari Kauppinen
    Research
    Nature Genetics
    Volume: 43, P: 371-378