Mucosal-associated invariant T (MAIT) cells sense riboflavin biosynthetic intermediate antigens with a semi-invariant MR1-restricted T-cell receptor (TCR). Here the authors identify a new MR1-restricted TCR that senses cells infected with S. pyogenes, a bacteria unable to biosynthesize riboflavin.
- Erin W. Meermeier
- Bruno F. Laugel
- David M. Lewinsohn