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Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins

Ke Shuai
Andrew Ziemiecki
James E. Darnell
Research09 Dec 1993
Nature

Volume: 366, P: 580-583
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder

Pamela Sklar and colleagues report a genome-wide association study of bipolar disorder and identify variants in the genes encoding ankyrin-3 and the alpha-1C subunit of the L-type voltage-gated calcium channel as increasing risk.

Manuel A R Ferreira
Michael C O'Donovan
Nick Craddock
Research17 Aug 2008
Nature Genetics

Volume: 40, P: 1056-1058
Ultrafast electronic relaxation pathways of the molecular photoswitch quadricyclane

Light-induced ultrafast switching between the molecular isomers norbornadiene and quadricyclane can reversibly store and release a substantial amount of chemical energy. Two competing pathways have now been identified by which electronically excited quadricyclane molecules relax to the electronic ground state, facilitating interconversion between the two isomers on different timescales.

Kurtis D. Borne
Joseph C. Cooper
Daniel Rolles
ResearchOpen Access02 Feb 2024
Nature Chemistry

Volume: 16, P: 499-505
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Dimethyl fumarate (DMF) is an anti-inflammatory drug proposed as a treatment for COVID19. Here the results are reported from a randomised trial testing DMF treatment in 713 patients hospitalised with COVID-19. DMF was not associated with any improvement in day 5 outcomes.

Peter Sandercock
Janet Darbyshire
Martin J. Landray
ResearchOpen Access31 Jan 2024
Nature Communications

Volume: 15, P: 1-13
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix

Targeting extracellular matrix (ECM) remodelling is a feasible avenue to prevent cancer aggressiveness and metastasis. In this study, Kay et al. show that metabolic flux in cancer-associated fibroblasts is coupled to enhanced proline synthesis by PYCR1 to support elevated production of collagen-rich ECM, thus contributing to cancer spreading.

Emily J. Kay
Karla Paterson
Sara Zanivan
ResearchOpen Access27 Jun 2022
Nature Metabolism

Volume: 4, P: 693-710
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4

The Psychiatric GWAS Consortium Bipolar Disorder Working Group reports a large-scale genome-wide association study of 7,481 individuals with bipolar disorder with replication in 4,493 cases. The Consortium identifies a new susceptibility locus near ODZ4 and replicates a known association near CACNA1C for bipolar disorder.

Pamela Sklar
Stephan Ripke
Shaun M Purcell
Research18 Sept 2011
Nature Genetics

Volume: 43, P: 977-983
How formaldehyde reacts with amino acids

Formaldehyde is the simplest biological electrophile, yet its reactivity with amino acids is not well understood. Here formaldehyde is shown to form a range of products with proteinogenic amino acids and simple peptides, including N-methyl lysine.

Jos J. A. G. Kamps
Richard J. Hopkinson
Timothy D. W. Claridge
ResearchOpen Access07 Nov 2019
Communications Chemistry

Volume: 2, P: 1-14
Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
Amendments and CorrectionsOpen Access11 Jul 2023
Nature

Volume: 619, P: E61
Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder

Simone de Jong et al. examine the balance of common and rare risk for psychiatric disorders in a large family with high incidence of Bipolar Disorder and Major Depressive Disorder. They find that increased polygenic risk over generations could be partially due to assortative mating, which may explain the observation of anticipation in mood disorders.

Simone de Jong
Mateus Jose Abdalla Diniz
Gerome Breen
ResearchOpen Access08 Oct 2018
Communications Biology

Volume: 1, P: 1-10

Search

Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder

Ultrafast electronic relaxation pathways of the molecular photoswitch quadricyclane

Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

A second update on mapping the human genetic architecture of COVID-19

Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix

Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4

How formaldehyde reacts with amino acids

Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder

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