Matrix metalloproteinases (MMPs) are a family of enzymes that have a number of important functions, including regulation of the extracellular matrix, angiogenesis and apoptosis. MMP dysregulation has been implicated in several disease processes. In this Review, the authors describe the role of MMPs in bladder cancer, and how these enzymes seem to have potential as diagnostic and prognostic biomarkers or as targets for therapy in patients with this disease.
- Tibor Szarvas
- Frank vom Dorp
- Herbert Rübben
