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Showing 1–16 of 16 results
Advanced filters: Author: Herman Waldmann Clear advanced filters

  • In this Viewpoint article, several experts share their thoughts on the plasticity and stability of regulatory T cells, discussing the recent advances in our understanding of the transcriptional and epigenetic regulation of this important T cell subset, as well as the therapeutic implications of this research.

    • Shimon Sakaguchi
    • Dario A. A. Vignali
    • Herman Waldmann
    Reviews
    Nature Reviews Immunology
    Volume: 13, P: 461-467

  • The immune system has evolved to ensure protection against ever changing microbial pathogens. The potential of lymphocytes to recognize 'self' is controlled by a process called 'self tolerance'. Improved understanding of the mechanisms of immunological tolerance is key to understanding the pathogenesis of autoimmune disorders and cancers, and may lead to strategies to harness tolerance to replace the lifelong need for immunosuppressive drugs after organ transplantation. In this Review, Waldmann provides an overview of the mechanisms of self tolerance and assesses the prospects of translating this knowledge to patient care.

    • Herman Waldmann
    Reviews
    Nature Reviews Nephrology
    Volume: 6, P: 569-576

  • Immunosuppression has been shown to induce tolerance to transplanted stem cells, but differentiation of these cells may trigger immune rejection later on. Here, Lui et al. show that a short-term immunosuppression regimen confers long-term tolerance to stem cells and their differentiated progeny.

    • Kathy O. Lui
    • Duncan Howie
    • Herman Waldmann
    Research
    Nature Communications
    Volume: 5, P: 1-13

  • “Cross-presentation” can prime CD8+ T cells. A transplantation system now reveals its role in destruction of the host endothelial cells that feed the graft.

    • Herman Waldmann
    News & Views
    Nature Immunology
    Volume: 3, P: 803-804

  • The immune system not only attacks microbes, but also regulates itself to avoid harming vital organs. Cells notorious for their involvement in allergy turn out to be vital to this protective function.

    • Herman Waldmann
    News & Views
    Nature
    Volume: 442, P: 987-988

  • Antibodies to the CD40 ligand have modulated the immune system in animal experiments and in human clinical trials. Assumptions about how these antibodies work are now reexamined (pages 1275–1280).

    • Herman Waldmann
    News & Views
    Nature Medicine
    Volume: 9, P: 1259-1260

  • Regulatory T cells are characterized by the expression of Foxp3, however, how the expression of this protein is controlled is unclear. Here, the authors show that the nuclear orphan receptor, Nr4a2, is a transcriptional activator of Foxp3, and suggest that it is required for the function of regulatory T cells.

    • Takashi Sekiya
    • Ikkou Kashiwagi
    • Akihiko Yoshimura
    ResearchOpen Access
    Nature Communications
    Volume: 2, P: 1-12

  • The European Lead Factory combines assets and experience from major pharma with innovation and agility of academia and SMEs in a collaborative platform to expand access to high-throughput screening. With many successes heading towards the clinic, the organization is broadening its approach to screening and partnering.

    • Philip S. Jones
    • Sylviane Boucharens
    • Jon S. B. de Vlieger
    Comments & Opinion
    Nature Reviews Drug Discovery
    Volume: 21, P: 245-246