Chemokines regulate the migration of immune cells into the liver in response to acute and chronic injuries and also have roles in stellate cell activation, hepatocyte proliferation and angiogenesis. In this Review, the authors describe experimental liver disease models in which chemokines and chemokine receptors have been studied, and highlight agents that are currently under clinical investigation for use in human diseases.
- Hacer Sahin
- Christian Trautwein
- Hermann E. Wasmuth
